Okorie Idika E, Afuecheta Emmanuel, Nadarajah Saralees, Bright Adaoma, Akpanta Anthony C
Department of Mathematics, Khalifa University, P. O. Box 127788, Abu Dhabi, UAE.
Department of Mathematics and Statistics, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia.
Sci Rep. 2024 Sep 16;14(1):21580. doi: 10.1038/s41598-024-72373-4.
In this paper, we have provided more insights on the relationship between under five morbidity in Nigeria and some background characteristics using a Poisson regression model and the most recent 2018 NDHS data on Acute Respiratory Infection (ARI), diarrhoea and fever. Some of our results are that children 36-47 months old have the highest risk of ARI [OR = 1.45; CI (1.31,1.60)] while children less than 6 months old have the lowest risk of ARI [OR = 0.14; CI (0.11,0.17)]. The prevalence of diarrhoea is generally high among children under 48-59 months old but highest among children 6-11 months old [OR = 4.34; CI (3.69,5.09)]. Compared to children 48-59 months old, children in all other age categories except 24-34 months old have a high risk of fever [OR = 0.95; CI (0.73,1.24)]. ARI is more prevalent among female children [OR = 8.88; CI (8.02,9.82)] while diarrhoea [OR = 21.75; (19.10,24.76)] and fever [OR = 4.78; CI (4.31,5.32)] are more prevalent among male children. Children in urban areas are more likely to suffer ARI [OR = 9.49; CI (8.31,10.85)] while children in rural areas are more likely to suffer both diarrhoea [OR = 21.75; CI (19.10,24.76)] and fever [OR = 4.90; CI (4.26,5.63)]. Children in the South-South have the highest risk of ARI [OR = 4.03; CI (3.65,4.454)] while children in the North Central have the lowest risk of ARI [OR = 1.55; CI (1.38,1.74)] and highest risk of diarrhoea [OR = 3.34; CI (2.30,5.11)]. Children in the Northeast have the highest risk of fever [OR = 1.30; CI (1.14,1.48)]. In the Northcentral region, Kogi state has the highest prevalence of fever [OR = 2.27; CI (1.62,3.17)], while Benue state has the lowest [OR = 0.35; CI (0.20,0.60)]. Children in Abuja state face similar risks of fever and diarrhoea [OR = 0.84; CI (0.55,1.27)], with the risk of diarrhoea in Abuja being comparable to that in Plateau state [OR = 1.57; CI (0.92,2.70)]. Nasarawa state records the highest incidence of diarrhoea in the Northcentral [OR = 5.12; CI (3.03,8.65)], whereas Kogi state reports the lowest [OR = 0.29; CI (0.16,0.53)]. In the Northeast, Borno state has the highest rate of fever [OR = 3.28; CI (2.80,3.84)], and Bauchi state the lowest [OR = 0.38; CI (0.29,0.50)]. In Adamawa state, the risks of fever and diarrhoea are nearly equivalent [OR = 1.17; CI (0.97,1.41)], and the risk of fever there is similar to that in Taraba state [OR = 0.92; CI (0.75,1.12)]. Diarrhoea is most prevalent in Yobe state [OR = 3.17; CI (2.37,4.23)] and least prevalent in Borno state [OR = 0.26; CI (0.20,0.33)]. In the Northwest, the risk of fever is similarly high in Zamfara and Kebbi states [OR = 1.04; CI (0.93,1.17)], with Kastina state showing the lowest risk [OR = 0.39; CI (0.34,0.46)]. Children in Zamfara state experience notably different risks of fever and diarrhoea [OR = 0.07; CI (0.05,0.10)]. Kaduna state reports the highest incidence of diarrhoea [OR = 21.88; CI (15.54,30.82)], while Kano state has the lowest [OR = 2.50; CI (1.73,3.63)]. In the Southeast, Imo state leads in fever incidence [OR = 8.20; CI (5.61,11.98)], while Anambra state has the lowest [OR = 0.40; CI (0.21,0.78)]. In Abia state, the risk of fever is comparable to that in Enugu state [OR = 1.03; CI (0.63,1.71)], but the risks of fever and diarrhoea in Abia differ significantly [OR = 2.67; CI (1.75,4.06)]. Abia state also has the highest diarrhoea rate in the Southeast [OR = 2.67; CI (1.75,4.06)], with Ebonyi state having the lowest [OR = 0.05; CI (0.03,0.09)]. In the South-South region, Bayelsa and Edo states have similar risks of fever [OR = 1.28; CI (0.84,1.95)], with Akwa Ibom state reporting the highest fever rate [OR = 4.62; CI (3.27,6.52)] and Delta state the lowest [OR = 0.08; CI (0.02,0.25)]. Children in Bayelsa state face distinctly different risks of fever and diarrhoea [OR = 0.56; CI (0.34,0.95)]. Rivers state shows the highest incidence of diarrhoea in the South-South [OR = 10.50; CI (4.78,23.06)], while Akwa Ibom state has the lowest [OR = 0.30; CI (0.15,0.57)]. In the Southwest, Lagos and Osun states have similar risks of fever [OR = 1.00; CI (0.59,1.69)], with Ogun state experiencing the highest incidence [OR = 3.47; CI (2.28,5.28)] and Oyo state the lowest [OR = 0.18; CI (0.07,0.46)]. In Lagos state, the risks of fever and diarrhoea are comparable [OR = 0.96; CI (0.57,1.64)], and the risk of diarrhoea is similar to those in Ekiti, Ogun, and Ondo states. Oyo state has the highest diarrhoea rate in the Southwest [OR = 10.99; CI (3.81,31.67)], with Ogun state reporting the lowest [OR = 0.77; CI (0.42,1.42)]. Children of mothers with more than secondary education are significantly less likely to suffer ARI [OR = 0.35; CI (0.29,0.42)], whereas children of mothers without any education run a higher risk of diarrhoea [OR = 2.12; CI (1.89,2.38)] and fever [OR = 2.61; CI (2.34,2.91)]. Our analysis also indicated that household wealth quintile is a significant determinant of morbidity. The results in this paper could help the government and non-governmental agencies to focus and target intervention programs for ARI, diarrhoea and fever on the most vulnerable and risky under five groups and populations in Nigeria.
在本文中,我们使用泊松回归模型以及2018年最新的尼日利亚人口与健康调查(NDHS)中关于急性呼吸道感染(ARI)、腹泻和发烧的数据,对尼日利亚五岁以下儿童发病率与一些背景特征之间的关系进行了更深入的研究。我们的一些研究结果如下:36 - 47个月大的儿童患ARI的风险最高[比值比(OR)= 1.45;置信区间(CI)(1.31, 1.60)],而6个月以下的儿童患ARI的风险最低[OR = 0.14;CI(0.11, 0.17)]。腹泻的患病率在48 - 59个月以下的儿童中普遍较高,但在6 - 11个月大的儿童中最高[OR = 4.34;CI(3.69, 5.09)]。与48 - 59个月大的儿童相比,除24 - 34个月大的儿童外,所有其他年龄段的儿童发烧风险都较高[OR = 0.95;CI(0.73, 1.24)]。ARI在女童中更为普遍[OR = 8.88;CI(8.02, 9.82)],而腹泻[OR = 21.75;(19.10, 24.76)]和发烧[OR = 4.78;CI(4.31, 5.32)]在男童中更为普遍。城市地区的儿童更易患ARI[OR = 9.49;CI(8.31, 10.85)],而农村地区的儿童更容易患腹泻[OR = 21.75;CI(19.10, 24.76)]和发烧[OR = 4.90;CI(4.26, 5.63)]。南南地区的儿童患ARI的风险最高[OR = 4.03;CI(3.65, 4.454)],而中北部地区的儿童患ARI的风险最低[OR = 1.55;CI(1.38, 1.74)],但患腹泻的风险最高[OR = 3.34;CI(2.30, 5.11)]。东北地区的儿童发烧风险最高[OR = 1.30;CI(1.14, 1.48)]。在中北部地区,科吉州发烧的患病率最高[OR = 2.27;CI(1.62, 3.17)],而贝努埃州最低[OR = 0.35;CI(0.20, 0.60)]。阿布贾州的儿童面临类似的发烧和腹泻风险[OR = 0.84;CI(0.55, 1.27)],阿布贾的腹泻风险与高原州相当[OR = 1.57;CI(0.92, 2.70)]。纳萨拉瓦州在中北部地区腹泻发病率最高[OR = 5.12;CI(3.03, 8.65)],而科吉州报告的发病率最低[OR = 0.29;CI(0.16, 0.53)]。在东北地区,博尔诺州发烧率最高[OR = 3.28;CI(2.80, 3.84)],而包奇州最低[OR = 0.38;CI(0.29, 0.50)]。在阿达马瓦州,发烧和腹泻的风险几乎相等[OR = 1.17;CI(0.97, 1.41)],该州的发烧风险与塔拉巴州相似[OR = 0.92;CI(0.75, 1.12)]。腹泻在约贝州最为普遍[OR = 3.17;CI(2.37, 4.23)],在博尔诺州最不普遍[OR = 0.26;CI(0.20, 0.33)]。在西北部地区,赞法拉州和凯比州发烧风险同样较高[OR = 1.04;CI(0.93, 1.17)],卡齐纳州风险最低[OR = 0.39;CI(0.34, 0.46)]。赞法拉州的儿童发烧和腹泻风险明显不同[OR = 0.07;CI(0.05, 0.10)]。卡杜纳州腹泻发病率最高[OR = 21.88;CI(15.54, 30.82)],而卡诺州最低[OR = 2.50;CI(1.73, 3.63)]。在东南部地区,伊莫州发烧发病率最高[OR = 8.20;CI(5.61, 11.98)],而阿南布拉州最低[OR = 0.40;CI(0.21, 0.78)]。在阿比亚州,发烧风险与埃努古州相当[OR = 1.03;CI(0.63, 1.71)],但阿比亚州的发烧和腹泻风险差异显著[OR = 2.67;CI(1.75, 4.06)]。阿比亚州在东南部地区腹泻率也最高[OR = 2.67;CI(1.75, 4.06)],埃邦伊州最低[OR = 0.05;CI(0.03, 0.09)]。在南南地区,巴耶尔萨州和江户州发烧风险相似[OR = 1.28;CI(0.84, 1.95)],阿夸伊博姆州发烧率最高[OR = 4.62;CI(3.27, 6.52)],三角州州最低[OR = 0.08;CI(0.02, 0.25)]。巴耶尔萨州的儿童发烧和腹泻风险明显不同[OR = 0.56;CI(0.34, 0.95)]。河流州在南南地区腹泻发病率最高[OR = 10.50;CI(4.78, 23.06)],而阿夸伊博姆州最低[OR = 0.30;CI(0.15, 0.57)]。在西南部地区,拉各斯州和奥孙州发烧风险相似[OR = 1.00;CI(0.59, 1.69)],奥贡州发病率最高[OR = 3.47;CI(2.28, 5.28)],奥约州最低[OR = 0.18;CI(0.07, 0.46)]。在拉各斯州,发烧和腹泻风险相当[OR = 0.96;CI(0.57, 1.64)],腹泻风险与埃基蒂州、奥贡州和翁多州相似。奥约州在西南部地区腹泻率最高[OR = 10.99;CI(3.81, 31.67)],奥贡州报告的发病率最低[OR = 0.77;CI(0.42, 1.42)]。母亲受过高中以上教育的儿童患ARI的可能性显著降低[OR = 0.35;CI(0.29, 0.42)],而母亲未受过任何教育的儿童患腹泻[OR = 2.12;CI(1.89, 2.38)]和发烧[OR = 2.61;CI(2.34, 2.91)]的风险更高。我们的分析还表明,家庭财富五分位数是发病率的一个重要决定因素。本文的研究结果有助于政府和非政府机构将针对ARI、腹泻和发烧的干预项目重点关注和瞄准尼日利亚五岁以下最脆弱和风险最高的群体及人群。