Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Clinical Research Unit, Institute of Clinical Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Department of Cardiology, Kailuan General Hospital, 57 Xinhua East Rd, Tangshan, 063000, Hebei Province, China.
Nutr J. 2024 Sep 17;23(1):107. doi: 10.1186/s12937-024-01013-4.
This study aimed to evaluate the association between different levels of physical activity and risk of developing type 2 diabetes (T2D) mellitus among adults with prediabetes in Chinese population.
This prospective population-based cohort study included 12,424 participants (mean [SD] age, 52.8 [16.8] years; 82.2% men) with prediabetes at 2014 survey of the Kailuan study. Physical activity information was collected through the International Physical Activity Questionnaire-Short Form and categorized by metabolic equivalent (MET) of task as low, moderate, and high. Cox regression models were built to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between physical activity levels and incident T2D.
During a median follow-up of 3.6 years, 2,207 (17.8%) participants developed T2D. The incident rate of T2D were 55.83/1000, 35.14/1000, and 39.61/1000 person-years in the low, moderate, and high physical activity level group, respectively. Both moderate (HR 0.57, 95% CI 0.49 to 0.67) and high (HR 0.76, 95% CI 0.66 to 0.89) physical activity levels were associated with lower risks of developing T2D compared to low physical activity level (P for trend < 0.001). The association between high physical activity level and T2D was primarily observed in participants without metabolic syndrome (P for interaction < 0.001). Moreover, participants with moderate or high levels of physical activity had significantly decreased fasting blood glucose levels during follow-up when compared to those with low level (P group*time < 0.001).
This study suggested that individuals with prediabetes might benefit from moderate and high levels of physical activity.
本研究旨在评估中国人群中，不同水平的体力活动与糖尿病前期成年人发生 2 型糖尿病（T2D）风险之间的关联。
本前瞻性基于人群的队列研究纳入了 12424 名参与者（平均[标准差]年龄 52.8[16.8]岁；82.2%为男性），他们在 2014 年的开滦研究调查中患有糖尿病前期。通过国际体力活动问卷-短表收集体力活动信息，并根据任务的代谢当量（MET）分为低、中、高体力活动水平。使用 Cox 回归模型来估计体力活动水平与 T2D 发病风险之间的关联的风险比（HR）和 95%置信区间（CI）。
在中位随访 3.6 年期间，有 2207 名（17.8%）参与者发生了 T2D。低、中、高体力活动水平组的 T2D 发生率分别为 55.83/1000、35.14/1000 和 39.61/1000 人年。与低体力活动水平相比，中（HR 0.57，95%CI 0.49 至 0.67）和高（HR 0.76，95%CI 0.66 至 0.89）体力活动水平均与 T2D 发病风险降低相关（趋势 P<0.001）。高体力活动水平与 T2D 之间的关联主要在没有代谢综合征的参与者中观察到（交互作用 P<0.001）。此外，与低水平体力活动相比，中或高水平体力活动的参与者在随访期间的空腹血糖水平显著降低（组*时间 P<0.001）。
本研究表明，糖尿病前期患者可能受益于中高强度的体力活动。
