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基于双变量克莱顿 copula 模型下左截断竞争风险数据的贝叶斯参数估计。

Bayesian parametric estimation based on left-truncated competing risks data under bivariate Clayton copula models.

作者信息

Michimae Hirofumi, Emura Takeshi, Miyamoto Atsushi, Kishi Kazuma

机构信息

School of Pharmacy, Department of Clinical Medicine (Biostatistics), Kitasato University, Tokyo, Japan.

Biostatistics Center, Kurume University, Kurume, Japan.

出版信息

J Appl Stat. 2024 Feb 22;51(13):2690-2708. doi: 10.1080/02664763.2024.2315458. eCollection 2024.

Abstract

In observational/field studies, competing risks and left-truncation may co-exist, yielding 'left-truncated competing risks' settings. Under the assumption of independent competing risks, parametric estimation methods were developed for left-truncated competing risks data. However, competing risks may be dependent in real applications. In this paper, we propose a Bayesian estimator for both independent competing risks and copula-based dependent competing risks models under left-truncation. The simulations show that the Bayesian estimator for the copula-based dependent risks model yields the desired performance when competing risks are dependent. We also comprehensively explore the choice of the prior distributions (Gamma, Inverse-Gamma, Uniform, half Normal and half Cauchy) and hyperparameters via simulations. Finally, two real datasets are analyzed to demonstrate the proposed estimators.

摘要

在观察性/实地研究中,竞争风险和左截断可能同时存在,产生“左截断竞争风险”情况。在独立竞争风险的假设下,针对左截断竞争风险数据开发了参数估计方法。然而,在实际应用中竞争风险可能是相关的。在本文中,我们针对左截断情况下的独立竞争风险模型和基于 copula 的相关竞争风险模型提出了一种贝叶斯估计器。模拟结果表明,当竞争风险相关时,基于 copula 的相关风险模型的贝叶斯估计器具有理想的性能。我们还通过模拟全面探讨了先验分布(伽马分布、逆伽马分布、均匀分布、半正态分布和半柯西分布)和超参数的选择。最后,分析了两个真实数据集以展示所提出的估计器。

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Bivariate copula regression models for semi-competing risks.双变量 Copula 回归模型在半竞争风险中的应用。
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本文引用的文献

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Permutation Tests for General Dependent Truncation.一般相依截断的排列检验
Comput Stat Data Anal. 2018 Dec;128:308-324. doi: 10.1016/j.csda.2018.07.012. Epub 2018 Jul 29.

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