Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, 610000, China.
National Engineering Laboratory for Clean Technology of Leather Manufacture, College of Biomass Science and Engineering, Sichuan University, Chengdu, 610000, China.
Biomaterials. 2025 Mar;314:122841. doi: 10.1016/j.biomaterials.2024.122841. Epub 2024 Sep 14.
Diabetic wound (DW), notorious for prolonged healing processes due to the unregulated immune response, neuropathy, and persistent infection, poses a significant challenge to clinical management. Current strategies for treating DW primarily focus on alleviating the inflammatory milieu or promoting angiogenesis, while limited attention has been given to modulating the neuro-immune microenvironment. Thus, we present an electrically conductive hydrogel dressing and identify its neurogenesis influence in a nerve injury animal model initially by encouraging the proliferation and migration of Schwann cells. Further, endowed with the synergizing effect of near-infrared responsive release of curcumin and nature-inspired artificial heterogeneous melanin nanoparticles, it can harmonize the immune microenvironment by restoring the macrophage phenotype and scavenging excessive reactive oxygen species. This in-situ formed hydrogel also exhibits mild photothermal therapy antibacterial efficacy. In the infected DW model, this hydrogel effectively supports nerve regeneration and mitigates the immune microenvironment, thereby expediting the healing progress. The versatile hydrogel exhibits significant therapeutic potential for application in DW healing through fine-tuning the neuro-immune microenvironment.
糖尿病创面（DW）由于免疫反应失调、神经病变和持续感染，导致愈合过程延长，给临床管理带来了巨大挑战。目前治疗 DW 的策略主要集中在缓解炎症环境或促进血管生成，而对调节神经免疫微环境的关注有限。因此，我们提出了一种具有导电性的水凝胶敷料，并通过促进雪旺细胞的增殖和迁移，初步在神经损伤动物模型中确定了其神经发生的影响。此外，由于姜黄素近红外响应释放和受自然启发的人工异质黑色素纳米粒子的协同作用，它可以通过恢复巨噬细胞表型和清除过多的活性氧来协调免疫微环境。这种原位形成的水凝胶还具有温和的光热治疗抗菌功效。在感染的 DW 模型中，这种水凝胶有效地支持神经再生并减轻免疫微环境，从而加速愈合过程。这种多功能水凝胶通过精细调节神经免疫微环境，在 DW 治疗方面显示出了显著的治疗潜力。
