Treatment of gonorrhea with clavulanate-potentiated amoxicillin (Augmentin).

One hundred sixty-one patients with culture-proved Neisseria gonorrhoeae infection were treated with a single oral dose of amoxicillin trihydrate (3 g) and potassium clavulanate (Augmentin, 0.25 g). Of 153 patients infected with non-penicillinase-producing strains of N. gonorrhoeae, 139 (91%) were cured, and five (62.5%) of eight patients infected with penicillinase-producing N. gonorrhoeae were cured. Augmentin was successful in eradicating N. gonorrhoeae from the rectum; 30 (97%) of 31 such infections were cured.