Department of Neurosciences, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
J Med Life. 2024 Jun;17(6):639-643. doi: 10.25122/jml-2024-0319.
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by diverse motor and non-motor symptoms. Visual evoked potentials (VEPs) provide valuable insights into the neurological changes in PD. This study examines VEP latency to explore potential connections between visual processing and PD progression, focusing on whether inter-eye latency differences are influenced by disease severity and symptomatology. A cross-sectional observational study was conducted with 59 PD patients at the Neurology I Clinic, Cluj-Napoca County Emergency Clinical Hospital, from October 2019 to October 2021. Patients underwent neurological and psychological evaluations, including VEP testing with a reversal pattern technique. P100 wave latency was assessed for both eyes, and associations with clinical indicators like Hoehn and Yahr stages, UPDRS scores, and non-motor symptoms were analyzed. VEP latencies for the right and left eyes were 108.7 ± 10.6 ms and 108.4 ± 9.7 ms, respectively, with no significant inter-eye differences ( = 0.8). UPDRS item 4 scores correlated significantly with both latencies ( = 0.003 for the left eye and <0.001 for the right). Latency differences between eyes were shorter in patients with symmetrical parkinsonism compared to those with unilateral predominance. Age correlated weakly with P100 latency, and a weak correlation was found between anhedonia scores and right-eye latency. VEP latency is sensitive to PD motor severity, with shorter inter-eye latency differences in symmetrical parkinsonism, suggesting balanced dopaminergic dysfunction. VEP latency differences offer insights into neurophysiological changes in PD, reflecting dopaminergic dysfunction and its impact on visual processing. These findings support the potential of VEPs as diagnostic and prognostic tools in PD assessment.
帕金森病（PD）是一种复杂的神经退行性疾病，其特征是多种运动和非运动症状。视觉诱发电位（VEPs）为 PD 中的神经变化提供了有价值的见解。本研究通过检查 VEP 潜伏期来探索视觉处理与 PD 进展之间的潜在联系，重点研究眼间潜伏期差异是否受到疾病严重程度和症状的影响。这是一项在 2019 年 10 月至 2021 年 10 月期间在克卢日-纳波卡县紧急临床医院神经 I 诊所进行的 PD 患者的横断面观察性研究。患者接受了神经学和心理学评估，包括使用反转模式技术进行 VEP 测试。评估了双眼的 P100 波潜伏期，并分析了与临床指标（如 Hoehn 和 Yahr 分期、UPDRS 评分和非运动症状）的关联。右眼和左眼的 VEP 潜伏期分别为 108.7 ± 10.6 ms 和 108.4 ± 9.7 ms，双眼之间无显著差异（ = 0.8）。UPDRS 第 4 项得分与潜伏期显著相关（左眼为 0.003，右眼为 <0.001）。与单侧优势相比，对称性帕金森病患者双眼之间的潜伏期差异更短。年龄与 P100 潜伏期呈弱相关，快感缺失评分与右眼潜伏期呈弱相关。VEP 潜伏期对 PD 运动严重程度敏感，对称性帕金森病患者双眼之间的潜伏期差异较小，表明多巴胺能功能障碍平衡。VEP 潜伏期差异提供了 PD 中神经生理变化的见解，反映了多巴胺能功能障碍及其对视觉处理的影响。这些发现支持 VEP 作为 PD 评估中诊断和预后工具的潜力。
