Bahadoran Zahra, Mirmiran Parvin, Azizi Fereidoun, Ghasemi Asghar
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bioimpacts. 2024;14(5):29917. doi: 10.34172/bi.2024.29917. Epub 2024 Feb 14.
We aimed to track longitudinal changes of glycemic status in subjects with pre-diabetes (Pre-DM) in relation to their baseline levels of systemic nitric oxide (NO) production [i.e., measured as serum NO metabolites (NOx), crude and body weight (BW)-adjusted NOx to creatinine ratio (NOx-to-Cr)] over 9 years.
This cohort study included 541 middle-aged Iranian men and women with Pre-DM, recruited in 2006-2008 and followed up to 2015-2017. The colorimetric Griess method was used to measure serum NOx concentration. Multinomial logistic regression analyses estimated the odds ratios (OR) of Pre-DM regression and progression across tertiles (tertile 3 tertile 1 and tertile 2) of serum NOx, crude, and BW-adjusted NOx-to-Cr ratio.
Participants who regressed to normoglycemia (NG) had a higher BW-adjusted NOx-to-Cr ratio than those who developed type 2 diabetes (T2D) or those who remained Pre-DM (0.52±0.34 0.43±0.25 and 0.48±0.29, =0.023). Higher BW-adjusted NOx-to-Cr increased chance of returning to NG (OR=2.05, 95% CI= 0.98-4.32, =0.058) and decreased levels of 2h-serum glucose over time ( =0.025), as well as the decreased overall mean of fasting (106, 95% CI=103-109 110, 95% CI=108-112 mg/dL, =0.008) and 2h-serum glucose (153, 95% CI=146-159 163, 95% CI=158-168 mg/dL, =0.018).
A higher endogenous NO production (i.e., indirectly measured by BW- and Cr-adjusted serum NOx concentration) in Pre-DM subjects is associated with the chance of returning to NG.
我们旨在追踪糖尿病前期（Pre-DM）患者血糖状态的纵向变化，并将其与9年间全身一氧化氮（NO）生成的基线水平[即通过血清NO代谢产物（NOx）、粗NOx以及体重（BW）校正的NOx与肌酐比值（NOx-to-Cr）来衡量]相关联。
这项队列研究纳入了541名患有糖尿病前期的伊朗中年男性和女性，于2006 - 2008年招募，并随访至2015 - 2017年。采用比色法Griess法测量血清NOx浓度。多项逻辑回归分析估计了血清NOx、粗NOx以及体重校正的NOx-to-Cr比值三分位数（三分位数3＞三分位数1和三分位数2）中糖尿病前期逆转和进展的比值比（OR）。
血糖恢复正常（NG）的参与者体重校正的NOx-to-Cr比值高于发生2型糖尿病（T2D）或仍处于糖尿病前期的参与者（0.52±0.34 vs 0.43±0.25和0.48±0.29，P = 0.023）。较高的体重校正NOx-to-Cr增加了恢复到血糖正常的几率（OR = 2.05，95%置信区间 = 0.98 - 4.32，P = 0.058），并随时间降低了2小时血清葡萄糖水平（P = 0.025），以及空腹血糖（106，95%置信区间 = 103 - 109 vs 110，95%置信区间 = 108 - 112 mg/dL，P = 0.008）和2小时血清葡萄糖（153，95%置信区间 = 146 - 159 vs 163，95%置信区间 = 158 - 168 mg/dL，P =
