Daly L E, Graham I M, Hickey N, Mulcahy R
Br Med J (Clin Res Ed). 1985 Oct 5;291(6500):935-7. doi: 10.1136/bmj.291.6500.935.
This study was designed to determine the relation between stopping smoking and angina after infarction in survivors of an acute coronary attack. The study population comprised 408 men aged under 60 who survived a first attack of unstable angina or myocardial infarction by 28 days and were smoking cigarettes at the time of their attack. These patients were followed up for an average of nine years. Three hundred and eighty four were alive at the one year follow up examination, when the presence or absence of angina together with habits of smoking were recorded. The prevalence of angina at one year was 19.5% in the 241 who had stopped smoking cigarettes compared with 32.2% in those who had continued (p less than 0.01). Six years later, however, the prevalence of angina after infarction was the same in the two groups. It is concluded that the onset of angina after infarction can be delayed by stopping smoking cigarettes but that this effect is not maintained in the long term.
本研究旨在确定急性冠状动脉发作幸存者心肌梗死后戒烟与心绞痛之间的关系。研究对象包括408名60岁以下的男性,他们在首次发作不稳定型心绞痛或心肌梗死后存活28天,且在发作时正在吸烟。这些患者平均随访了九年。在一年的随访检查时,384人存活,记录了他们是否患有心绞痛以及吸烟习惯。在241名已戒烟者中,一年内心绞痛的患病率为19.5%,而继续吸烟者为32.2%(p<0.01)。然而,六年后,两组心肌梗死后心绞痛的患病率相同。结论是,戒烟可延迟心肌梗死后心绞痛的发作,但这种效果不能长期维持。