Department of Nutrition and Food Hygiene, School of Public Health, the National Key Discipline, Harbin Medical University, 157 Baojian Road, Harbin, 150081, P. R. China.
Int J Behav Nutr Phys Act. 2024 Sep 19;21(1):104. doi: 10.1186/s12966-024-01654-y.
Information on the influences of daily eating frequency (DEF) and nighttime fasting duration (NFD) on biological aging is minimal. Our study investigated the potential associations of DEF and NFD with accelerated aging.
Out of 24212 participants in NHANES 2003-2010 and 2015-2018, 4 predicted age metrics [homeostatic dysregulation (HD), Klemera-Doubal method (KDM), phenoAge (PA), and allostatic load (AL)] were computed based on 12 blood chemistry parameters. Utilizing 24-h dietary recall, DEF was measured by the frequency of eating occurrences, while NFD was determined by assessing the timing of the initial and final meals throughout the day. Weighted multivariate linear regression models and restricted cubic spline (RCS) were utilized to examine the associations.
Compared to DEF of ≤ 3.0 times, subjects with DEF ≥ 4.6 times demonstrated lower KDM residual [β: -0.57, 95% confidence-interval (CI): (-0.97, -0.17)] and PA residual [β: -0.47, 95% CI: (-0.69, -0.25)]. In comparison to NFD between 10.1 and 12.0 h, individuals with NFD ≤ 10.0 h were at higher HD [β: 0.03, 95% CI: (0.01, 0.04)], KDM residual [β: 0.34, 95% CI: (0.05, 0.63)], and PA residual [β: 0.38, 95% CI: (0.18, 0.57)]. Likewise, those with NFD ≥ 14.1 h also had higher HD [β: 0.02, 95% CI: (0.01, 0.04)] and KDM residual [β: 0.33, 95% CI: (0.03, 0.62)]. The results were confirmed by the dose-response relationships of DEF and NFD with predicted age metrics. Lactate dehydrogenase (LDH) and globulin (Glo) were acknowledged as implicated in and mediating the relationships.
DEF below 3.0 times and NFD less than 10.0 or more than 14.1 h were independently associated with higher predicted age metrics.
关于每日进食频率（DEF）和夜间禁食时间（NFD）对生物衰老影响的信息很少。我们的研究调查了 DEF 和 NFD 与加速衰老之间的潜在关联。
在 NHANES 2003-2010 年和 2015-2018 年的 24212 名参与者中，根据 12 项血液化学参数计算了 4 种预测年龄指标[体内平衡失调（HD）、Klemera-Doubal 方法（KDM）、表型年龄（PA）和全身负荷（AL）]。利用 24 小时膳食回顾法，通过进食次数的频率来衡量 DEF，通过评估一天中初始和最后一顿饭的时间来确定 NFD。使用加权多变量线性回归模型和限制性三次样条（RCS）来检查关联。
与 DEF 频率≤3.0 次相比，DEF 频率≥4.6 次的受试者的 KDM 残差[β：-0.57，95%置信区间（CI）：（-0.97，-0.17）]和 PA 残差[β：-0.47，95% CI：（-0.69，-0.25）]较低。与 NFD 为 10.1 至 12.0 小时相比，NFD 为 10.0 小时以下的个体 HD [β：0.03，95% CI：（0.01，0.04）]、KDM 残差[β：0.34，95% CI：（0.05，0.63）]和 PA 残差[β：0.38，95% CI：（0.18，0.57）]较高。同样，NFD 为 14.1 小时以上的个体 HD [β：0.02，95% CI：（0.01，0.04）]和 KDM 残差[β：0.33，95% CI：（0.03，0.62）]也较高。DEF 和 NFD 与预测年龄指标之间的剂量-反应关系证实了这一结果。乳酸脱氢酶（LDH）和球蛋白（Glo）被认为与这些关系有关，并起到了中介作用。
DEF 低于 3.0 次，NFD 小于 10.0 小时或大于 14.1 小时与更高的预测年龄指标独立相关。
