Centre for High-Pressure Research, School of Physics, Bharathidasan University, Tiruchirappalli, 620024, Tamil Nadu, India.
International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City, 24301, Taiwan.
Mikrochim Acta. 2024 Sep 21;191(10):613. doi: 10.1007/s00604-024-06653-1.
The electrochemical detection characteristics of the layered TiCT material were enhanced by modifying its surface. TiCT is used as the Ti - F chemical bond weakens with increasing pH levels. TiCT is alkalinized by KOH, and F is substituted for - OH. The surface hydroxyl groups can be eliminated by intercalating K. This study elaborates on the hydrothermal production of vanadium-doped layered TiCT nanosheets intercalated with K. The development of a sensitive dopamine electrochemical sensor is outlined by intercalating a vanadium-doped multilayered K TiCT electrode. The chemical, surface, and structural composition of the synthesized electrode for dopamine detection was investigated and confirmed. The sensor exhibits a linear range (1-10 µM), a low detection limit (8.4 nM), and a high sensitivity of 2.746 µAµMcm under optimal electrochemical testing conditions. The sensor also demonstrates exceptional anti-interference capabilities and stability. The sensor was applied to detection of dopamine in (spiked) rat brains, human serum, and urine samples. This study introduces a novel approach by utilizing K intercalation of vanadium-doped TiCT-based electrochemical sensors and an innovative method for dopamine detection. The dopamine detection revealed the potential of (V0.05) K TiCT-GCE for practical application in pharmaceutical sample analysis.
通过修饰其表面来提高层状 TiCT 材料的电化学检测特性。TiCT 用作 Ti-F 化学键随 pH 值升高而减弱。TiCT 被 KOH 堿化，F 被 -OH 取代。通过插层 K 可以消除表面羟基。本研究详细阐述了层状 TiCT 纳米片的水热合成，该纳米片插层有 K 和掺杂的钒。通过插层掺杂多层 KTiCT 电极，概述了一种灵敏的多巴胺电化学传感器的开发。研究并证实了用于多巴胺检测的合成电极的化学、表面和结构组成。在最佳电化学测试条件下，该传感器具有线性范围（1-10 µM）、低检测限（8.4 nM）和高灵敏度 2.746 µAµMcm。该传感器还表现出出色的抗干扰能力和稳定性。该传感器已应用于（加标）大鼠脑、人血清和尿液样本中的多巴胺检测。本研究通过利用 K 插层的基于钒掺杂 TiCT 的电化学传感器和一种创新的多巴胺检测方法，介绍了一种新方法。多巴胺检测揭示了 (V0.05) KTiCT-GCE 在药物样品分析中的实际应用潜力。
