Yi Ruhan, Liu Yun, Zhang Xu, Sun Xiance, Wang Ningning, Zhang Cong, Deng Haoyuan, Yao Xiaofeng, Wang Shaopeng, Yang Guang
Department of Food Nutrition and Safety, Dalian Medical University, Dalian, China.
Department of Occupational & Environmental Health, Dalian Medical University, Dalian, China.
Phytother Res. 2024 Dec;38(12):5641-5656. doi: 10.1002/ptr.8332. Epub 2024 Sep 22.
The prevalence of diabetes is escalating alarmingly, placing a significant economic burden on the global healthcare system. The use of chemical substances extracted from plants has been demonstrated to be an effective method for the treatment and control of insulin resistance and Type 2 diabetes mellitus (T2DM). New research indicates that natural phytochemicals present in fruits and vegetables are expected to become drugs for the treatment of diabetes and the prevention of related complications. Quercetin, a widely distributed flavonoid, is well-known for its antioxidant, anti-inflammatory, anticancer, and antidiabetic properties. This article provides a comprehensive account of the mechanism of action of quercetin on diabetes and obesity complications in vivo and in vitro. It elucidates the impact of quercetin on various cells. These include hepatocytes, renal cells, skeletal muscle cells, and adipocytes. Furthermore, this article discusses the mechanism of quercetin on organ damage in diabetic mice induced by STZ, alloxan, diet, and spontaneous Type 2 diabetic mice caused by genetic defects. Additionally, it addresses the pharmacokinetics of quercetin and its potential for synergistic effects with existing diabetic drugs.
糖尿病的患病率正以惊人的速度攀升，给全球医疗系统带来了沉重的经济负担。已证明使用从植物中提取的化学物质是治疗和控制胰岛素抵抗及2型糖尿病（T2DM）的有效方法。新研究表明，水果和蔬菜中含有的天然植物化学物质有望成为治疗糖尿病及预防相关并发症的药物。槲皮素是一种广泛分布的黄酮类化合物，以其抗氧化、抗炎、抗癌和抗糖尿病特性而闻名。本文全面阐述了槲皮素在体内和体外对糖尿病及肥胖并发症的作用机制。它阐明了槲皮素对各种细胞的影响。这些细胞包括肝细胞、肾细胞、骨骼肌细胞和脂肪细胞。此外，本文还讨论了槲皮素对由链脲佐菌素（STZ）、四氧嘧啶、饮食诱导的糖尿病小鼠以及由基因缺陷导致的自发性2型糖尿病小鼠器官损伤的作用机制。此外，还探讨了槲皮素的药代动力学及其与现有糖尿病药物协同作用的潜力。
