[寄生于普通鼠妇体内的内生真菌马里科拟青霉的次生代谢产物]
[Secondary metabolites of endophytic fungus Talaromyces malicola hosted in Armadillidium vulgare].
作者信息
Yang Chen-Yu, Chen Ke-Liang, Liu Yang, Yi Cheng, Jia Xing-Bao, Liu Yun-Bao
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2024 Aug;49(16):4470-4476. doi: 10.19540/j.cnki.cjcmm.20240520.201.
The secondary metabolites of the endophytic fungus Talaromyces malicola hosted in the arthropod Armadillidium vulgare were separated by silica gel column chromatography, gel column chromatography, and semi-preparative high-performance liquid chromatography. Eleven compounds(1-11) were obtained from the ethyl acetate fraction of the fermentation broth of T. malicola, and their structures were identified by NMR, HR-ESI-MS, UV, IR, and ECD. The 11 compounds were talarosesquiterpene A(1),(3β,5α,6α,15α,22E)-5,6-epoxyergosta-8(14),22-diene-3,7,15-triol(2), vermistatin(3), hydroxyvermistatin(4), bercheminol A(5), penicillide(6), lunatinin(7), penipurdin A(8), emodin(9), BE-25327(10), and(-)-regiolone(11). Compound 1 was a new diaporol-type sesquiterpene. Compounds 2, 4-5, and 7-11 were isolated from Talaromyces for the first time.
寄生于节肢动物鼠妇（Armadillidium vulgare）体内的内生真菌马里科拉拟青霉（Talaromyces malicola）的次生代谢产物，通过硅胶柱色谱、凝胶柱色谱和半制备高效液相色谱进行分离。从马里科拉拟青霉发酵液的乙酸乙酯部分获得了11种化合物（1-11），并通过核磁共振（NMR）、高分辨电喷雾电离质谱（HR-ESI-MS）、紫外光谱（UV）、红外光谱（IR）和电子圆二色谱（ECD）对其结构进行了鉴定。这11种化合物分别为塔拉倍半萜A（1）、（3β,5α,6α,15α,22E）-5,6-环氧麦角甾-8（14）,22-二烯-3,7,15-三醇（2）、绿胶霉素（3）、羟基绿胶霉素（4）、贝切米诺醇A（5）、青霉内酯（6）、卢那替尼（7）、青霉嘌呤A（8）、大黄素（9）、BE-25327（10）和（-）-区域酮（11）。化合物1是一种新的二阿波醇型倍半萜。化合物2、4-5以及7-11均为首次从拟青霉属中分离得到。
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