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小反刍兽疫、传染性山羊胸膜肺炎、绵羊痘和山羊痘、巴氏杆菌病疫苗共同免疫接种对山羊的免疫应答和安全性。

Immune response and safety of co-administered peste des petits ruminants, contagious caprine pleuropneumonia, sheep and goat pox, and Pasteurellosis vaccines in goats.

机构信息

National Veterinary Institute, Bishoftu, Ethiopia.

Luna Export Abattoir, Central Oromia, Ethiopia.

出版信息

Open Vet J. 2024 Aug;14(8):1960-1967. doi: 10.5455/OVJ.2024.v14.i8.25. Epub 2024 Aug 31.

DOI:10.5455/OVJ.2024.v14.i8.25
PMID:39308707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11415898/
Abstract

BACKGROUND

Infectious diseases such as peste des petits ruminants (PPRs), contagious caprine pleuropneumonia (CCPP), sheep and goat pox (SGPX), and pasteurellosis have considerable impacts on the optimal utilization of sheep and goat resources in Ethiopia. Immunization using multiple vaccines administered simultaneously has been suggested as a cost-effective and safe approach to controlling and preventing these diseases.

AIM

The aim of this study was to assess the immunogenicity and safety of multiple vaccines administered simultaneously in goats.

METHODS

Sero-negative PPR, CCPP, SGPX, and Pasteurellosis goats were immunized with multiple vaccines. Goats vaccinated with a single vaccine against each disease served as a positive control. The immune response of the goats was assessed using serological tests, and any adverse effects were monitored.

RESULTS

The results of the present study showed that goats vaccinated with multiple vaccines exhibited a remarkable immune response against PPR, CCPP, and pasteurellosis. In contrast, they did not produce a protective immune response against sheep or goat pox. No adverse effects were observed with any of the vaccines.

CONCLUSION

This study suggested that combined vaccines can be effective at inducing a protective immune response in goats. However, further research is needed to fully understand the immune response to combined vaccines.

摘要

背景

绵羊和山羊传染病如小反刍兽疫（PPR）、传染性胸膜肺炎（CCPP）、绵羊痘和山羊痘（SGPX）和巴氏杆菌病对埃塞俄比亚充分利用绵羊和山羊资源有重大影响。同时使用多种疫苗进行免疫接种被认为是控制和预防这些疾病的一种具有成本效益且安全的方法。

目的

本研究旨在评估同时接种多种疫苗对山羊的免疫原性和安全性。

方法

对血清阴性的 PPR、CCPP、SGPX 和巴氏杆菌病山羊进行了多种疫苗接种。接种单一疫苗针对每种疾病的山羊作为阳性对照。使用血清学试验评估山羊的免疫反应，并监测任何不良反应。

结果

本研究结果表明，接种多种疫苗的山羊对 PPR、CCPP 和巴氏杆菌病表现出显著的免疫反应。相比之下，它们对绵羊或山羊痘没有产生保护性免疫反应。任何疫苗都没有观察到不良反应。

结论

本研究表明，联合疫苗可有效诱导山羊产生保护性免疫反应。然而，需要进一步研究来充分了解联合疫苗的免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/91efefae52c0/OpenVetJ-14-1960-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/8dff484d2477/OpenVetJ-14-1960-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/edb1739c2aef/OpenVetJ-14-1960-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/a7bf60ca6540/OpenVetJ-14-1960-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/a77388fe622a/OpenVetJ-14-1960-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/91efefae52c0/OpenVetJ-14-1960-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/8dff484d2477/OpenVetJ-14-1960-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/edb1739c2aef/OpenVetJ-14-1960-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/a7bf60ca6540/OpenVetJ-14-1960-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/a77388fe622a/OpenVetJ-14-1960-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baae/11415898/91efefae52c0/OpenVetJ-14-1960-g005.jpg

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Development of an inactivated combined vaccine for protection of cattle against lumpy skin disease and bluetongue viruses.研制一种灭活联合疫苗，以保护牛免受块状皮肤病和蓝舌病病毒的侵害。
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