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益生菌和微生物群对神经系统及精神疾病的影响。

The Effect of Probiotics and Microbiota on Nervous System and Mental Illnesses.

作者信息

Hossainpour Hadi, Khazaei Salman, Mahmoudi Hassan

机构信息

Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Department of Microbiology, School of Medicine, Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

Cent Nerv Syst Agents Med Chem. 2025;25(2):109-122. doi: 10.2174/0118715249315760240905043415.

Abstract

The microbiota that inhabits the gastrointestinal tract has been linked to various gastrointestinal and non-gastrointestinal disorders. Scientists have been studying how the bacteria in our intestines have an effect on our brain and nervous system. This connection is called the "microbiota-gut-brain axis". Given the capacity of probiotics, which are live non-pathogenic microorganisms, to reinstate the normal microbial population within the host and confer advantages, their potential impact has been subjected to scrutiny with regard to neurological and mental conditions. Material sourced for this review included peer-reviewed literature annotated in the PubMed, Web of Science, Scopus, and Google Scholar databases. The result has indicated the integration of probiotics into a child's diet to enhance the neuro-behavioral symptoms. Notwithstanding this, the current data set has been found to be insufficient and inconclusive. The potential utility of probiotics for the prevention or treatment of neurologic and mental disorders has become a subject of substantial interest.

摘要

栖息于胃肠道的微生物群已与各种胃肠道和非胃肠道疾病相关联。科学家们一直在研究我们肠道中的细菌如何影响我们的大脑和神经系统。这种联系被称为“微生物群-肠道-脑轴”。鉴于益生菌(即活的非致病微生物)有能力恢复宿主内的正常微生物群落并带来益处,它们在神经和精神疾病方面的潜在影响已受到审查。本综述的资料来源包括在PubMed、科学网、Scopus和谷歌学术数据库中注释的同行评审文献。结果表明,将益生菌纳入儿童饮食可改善神经行为症状。尽管如此,目前的数据集被发现是不充分且无定论的。益生菌在预防或治疗神经和精神疾病方面的潜在效用已成为一个备受关注的课题。

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