Brands Marjolein J, Loman Laura, Lund Tamara T, Flachs Esben M, Bültmann Ute, Schuttelaar Marie L A
Department of Dermatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark.
Contact Dermatitis. 2025 Jan;92(1):31-40. doi: 10.1111/cod.14687. Epub 2024 Sep 24.
Studies on wet work and hand eczema (HE) frequently rely solely on self-reports regarding wet work.
To assess the association between wet work and moderate-to-very-severe HE, within the Dutch general population, by using a (sex-specific) job exposure matrix (JEM).
Within the Lifelines Cohort Study, participants with self-reported moderate-to-very-severe HE at worst in the past year were linked to data from the Danish (sex-specific) wet work JEM, a tool that links occupations with wet work indices (including duration and probability of glove use, wet hands and total wet work for at least 2 and 4 h/working day).
In total, 56 978 (41.9%) participants were included. The multivariate binary logistic regression analyses showed significant associations between all facets of wet work and moderate-to-very-severe HE. When using the sex-specific JEM, significant associations were found in females, but not in males.
This study is the first to use a wet work-specific JEM in a general population sample, and found positive associations between wet work and HE. The sex-specific findings should be interpreted with caution, due to limitations inherent in using a JEM, and should be further explored with observational studies, with a focus on duration, frequency, and exposure type.
关于湿作业与手部湿疹（HE）的研究常常仅依赖于关于湿作业的自我报告。
通过使用（按性别划分的）工作暴露矩阵（JEM），评估荷兰普通人群中湿作业与中重度至非常重度手部湿疹之间的关联。
在生命线队列研究中，将过去一年中自我报告的手部湿疹最严重程度为中重度至非常重度的参与者与丹麦（按性别划分的）湿作业JEM数据相链接，该工具将职业与湿作业指数（包括戴手套的时长和概率、湿手情况以及每天至少2小时和4小时的总湿作业时长）相联系。
总共纳入了56978名（41.9%）参与者。多变量二元逻辑回归分析显示，湿作业的各个方面与中重度至非常重度手部湿疹之间均存在显著关联。使用按性别划分的JEM时，在女性中发现了显著关联，但在男性中未发现。
本研究首次在普通人群样本中使用特定于湿作业的JEM，并发现湿作业与手部湿疹之间存在正相关。由于使用JEM存在固有局限性，按性别划分的研究结果应谨慎解读，并且应以观察性研究进一步探索，重点关注时长、频率和暴露类型。
