Surján A, Kocsis Z, Csík M, Pintér A, Török G, Börzsönyi M, Szabad J
Mutat Res. 1985 Nov;144(3):177-81. doi: 10.1016/0165-7992(85)90136-8.
Mutagenic activity of 4 nitroso compounds of environmental importance - N-nitroso-morpholine, dinitrosopiperazine, N,N'-dinitroso-pyridinol-carbamate and N-methyl-N-nitroso-p-toluenesulfonamide - was tested by the Drosophila mosaic test. Larvae were fed with the nitroso-compound-containing food for 2-4 days, and when they had developed into adults, their wings were screened for mosaic spots. All 4 compounds were positive. This finding supports the conclusion that the mosaic test - besides other test procedures - may become a tool for identifying mutagens.
对4种具有环境重要性的亚硝基化合物——N-亚硝基吗啉、二亚硝基哌嗪、N,N'-二亚硝基吡啶醇-氨基甲酸盐和N-甲基-N-亚硝基对甲苯磺酰胺——的致突变活性进行了果蝇镶嵌体试验检测。用含亚硝基化合物的食物喂养幼虫2至4天，当它们发育成成虫后，检查其翅膀上的镶嵌斑。所有4种化合物的检测结果均为阳性。这一发现支持了以下结论：除其他检测方法外，镶嵌体试验可能会成为一种识别诱变剂的工具。
