三环芳烃型倍半萜类化合物的最新研究进展：生物活性与生物合成。

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

Zhejiang Institute of Tianjin University, Shaoxing 312300, China.

Biomolecules. 2024 Sep 7;14(9):1133. doi: 10.3390/biom14091133.

The tricyclic-aromadendrene-type sesquiterpenes are widely distributed and exhibit a range of biological activities, including anti-inflammatory, analgesic, antioxidant, antibacterial, insecticidal and cytotoxic properties. Several key sesquiterpene synthases (STSs) of this type have been identified, of which, viridiflorol synthase has been engineered for efficiently biosynthesizing viridiflorol in an strain. This paper comprehensively summarizes the distribution and biological activity of aromadendrene-type sesquiterpenes in plant essential oils and microorganisms. The progress in aromadendrene-type sesquiterpene biosynthesis research, including the modifications of key STSs and the optimization of synthetic pathways, is reviewed. Finally, the prospects and associated challenges for the application and biosynthesis of these natural products are also discussed.

三环阿瑞香烯型倍半萜广泛分布，具有多种生物活性，包括抗炎、镇痛、抗氧化、抗菌、杀虫和细胞毒性。已经鉴定出几种此类关键的倍半萜合酶 (STS)，其中，viridiflorol 合酶已被工程改造用于在菌株中高效生物合成 viridiflorol。本文全面总结了植物精油和微生物中阿瑞香烯型倍半萜的分布和生物活性。综述了三环阿瑞香烯型倍半萜生物合成研究的进展，包括关键 STS 的修饰和合成途径的优化。最后，还讨论了这些天然产物的应用和生物合成的前景和相关挑战。