Department of Physical Education, Zhengzhou Railway Vocational and Technical College, Zhengzhou, Henan, People's Republic of China.
Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Sci Rep. 2024 Mar 4;14(1):5247. doi: 10.1038/s41598-024-55898-6.
The study aimed to investigate the association between long-term sedentary behavior (LTSB) and depressive symptoms within a representative sample of the U.S. adult population. Data from NHANES 2017-2018 were used, encompassing information on demographics, depressive symptoms, physical activity (PA), and LTSB. Depressive symptoms were identified using the Patient Health Questionnaire (PHQ-9), with "depressive symptoms" defined as a PHQ-9 score of ≥ 5, and "moderate to severe depressive symptoms (MSDS)" defined as a PHQ-9 score of ≥ 10. PA and LTSB were assessed through the Global Physical Activity Questionnaire, where LTSB was interpreted as sedentary time ≥ 600 min. Restricted Cubic Spline (RCS) curves were utilized to observe potential nonlinear relationships. Binary Logistic regressions were conducted to analyze the associations. A total of 4728 participants (mean age 51.00 ± 17.49 years, 2310 males and 2418 females) were included in the study. Among these individuals, 1194 (25.25%) displayed depressive symptoms, with 417 (8.82%) exhibiting MSDS. RCS curves displayed increased risk of depressive symptoms with prolonged sedentary duration. Logistic regression models indicated significant associations between LTSB and depressive symptoms (OR 1.398, 95% CI 1.098-1.780), and LTSB and MSDS (OR 1.567, 95% CI 1.125-2.183), after adjusting for covariates. These findings suggest that LTSB may act as a potential risk factor for both depressive symptoms and MSDS in the studied population.
本研究旨在调查美国成年人群代表性样本中，长期久坐行为（LTSB）与抑郁症状之间的关联。研究数据来自 2017-2018 年 NHANES，包括人口统计学、抑郁症状、身体活动（PA）和 LTSB 信息。抑郁症状使用患者健康问卷（PHQ-9）进行评估，PHQ-9 评分≥5 分定义为“存在抑郁症状”，PHQ-9 评分≥10 分定义为“中重度抑郁症状（MSDS）”。PA 和 LTSB 通过全球体力活动问卷进行评估，其中 LTSB 定义为久坐时间≥600 分钟。限制性三次样条（RCS）曲线用于观察潜在的非线性关系。二项逻辑回归用于分析关联。共纳入 4728 名参与者（平均年龄 51.00±17.49 岁，男性 2310 名，女性 2418 名）。其中 1194 名（25.25%）存在抑郁症状，417 名（8.82%）存在 MSDS。RCS 曲线显示，久坐时间延长与抑郁症状风险增加相关。Logistic 回归模型表明，在调整协变量后，LTSB 与抑郁症状（OR 1.398，95%CI 1.098-1.780）和 MSDS（OR 1.567，95%CI 1.125-2.183）之间存在显著关联。这些发现表明，LTSB 可能是研究人群中抑郁症状和 MSDS 的潜在危险因素。
