Griskeviciene Urte, Dambrauskiene Justina, Marksa Mindaugas, Mazeliene Zaneta, Vainoriene Rimanta, Ivanauskas Liudas
Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania.
Department of Drug Chemistry, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania.
Life (Basel). 2024 Sep 20;14(9):1191. doi: 10.3390/life14091191.
(Savi) Ten. is a plant from the family that is commonly used in traditional medicine. The purpose of this work was to investigate the antioxidant and antimicrobial characteristics of phenolic compounds found in ethanol and dry extracts of leaves, inflorescence, and roots during various phenological stages. Apigenin-7--glucoside and chlorogenic acid were identified in practically all extracts. Extracts from leaves collected at the end of the phenological dormancy period and in the first growing year had the highest antioxidant (cupric ion-reducing antioxidant capacity of 12,938 Trolox equivalents/g dry weight) and antimicrobial activity (against , , , , and ) with MIC values of ethanol extract from 16.7 mg/mL to 8.35 mg/mL. These extracts included a high concentration of chlorogenic acid and apigenin-7--glucoside. Also, dry extracts from roots and inflorescences showed a higher antimicrobial effect compared to ethanolic extracts with MIC values from 5.57 mg/mL to 3 mg/mL. The study emphasizes the critical role of phenological stages and raw material composition in the accumulation of phenolic compounds and their biological activity in . The findings suggest that extracts from leaves, especially those collected at the end of the phonological dormancy period, are promising candidates for further research into bioactive compounds with potential medicinal applications. The strong antioxidant and antibacterial properties of these extracts highlight their potential for development into natural pharmaceutical products.
（萨维）Ten.是一种来自该科的植物，常用于传统医学。这项工作的目的是研究在不同物候阶段，叶片、花序和根的乙醇提取物及干提取物中酚类化合物的抗氧化和抗菌特性。在几乎所有提取物中都鉴定出了芹菜素-7-葡萄糖苷和绿原酸。在物候休眠期结束时和生长的第一年收集的叶片提取物具有最高的抗氧化（铜离子还原抗氧化能力为12,938 Trolox当量/克干重）和抗菌活性（对、、、和），乙醇提取物的最低抑菌浓度值为16.7毫克/毫升至8.35毫克/毫升。这些提取物含有高浓度的绿原酸和芹菜素-7-葡萄糖苷。此外，根和花序的干提取物与乙醇提取物相比显示出更高的抗菌效果，最低抑菌浓度值为5.57毫克/毫升至3毫克/毫升。该研究强调了物候阶段和原料组成在Ten.中酚类化合物积累及其生物活性方面的关键作用。研究结果表明，Ten.叶片的提取物，尤其是在物候休眠期结束时收集的提取物，是进一步研究具有潜在药用应用的生物活性化合物的有前途的候选物。这些提取物强大的抗氧化和抗菌特性突出了它们开发成天然药品的潜力。
