Programa de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
Faculdade de Educação Física e Fisioterapia, Universidade Federal do Amazonas, Manaus 69060-001, Brazil.
Viruses. 2024 Sep 9;16(9):1437. doi: 10.3390/v16091437.
Human Herpesviruses (HHVs) play a significant role in neurological diseases such as encephalitis and meningitis, adding significant morbidity. This study aims to retrospectively analyze the effect of HHVs on patients with neurological symptoms, focusing on the family's contributions to central nervous system (CNS) infections.
This retrospective cohort study included 895 patients suspected of viral CNS infections, utilizing molecular diagnosis via qPCR to identify HHVs in cerebrospinal fluid (CSF) samples. This was conducted at a reference tertiary care hospital for infectious diseases in the western Brazilian Amazon from January 2015 to December 2022, focusing on the family's clinical repercussions and of Cytomegalovirus in CNS infections.
The findings revealed that 7.5% of the analyzed samples tested positive for HHVs, with Human (HCMV) and Virus (EBV) being the most prevalent. A significant association was found between HHVs and neurological diseases such as encephalitis and meningitis, especially among people living with HIV/AIDS (PLWHA), highlighting the opportunistic nature of these viruses. The study underscores the critical role of CSF analysis in diagnosing CNS infections and the complexity of managing these infections in HIV patients due to their immunocompromised status.
The results emphasize the need for comprehensive diagnostic approaches and tailored treatment strategies for CNS infections in immunocompromised individuals. The study calls for ongoing research and advancements in clinical practice to improve patient outcomes facing CNS infections, particularly those caused by HHVs.
人类疱疹病毒（HHV）在脑炎和脑膜炎等神经疾病中起着重要作用，增加了发病率。本研究旨在回顾性分析 HHV 对有神经症状患者的影响，重点关注家庭对中枢神经系统（CNS）感染的贡献。
本回顾性队列研究纳入了 895 例疑似病毒性 CNS 感染患者，通过 qPCR 分子诊断在脑脊液（CSF）样本中识别 HHV。该研究于 2015 年 1 月至 2022 年 12 月在巴西西部亚马逊地区的一家传染病参考三级护理医院进行，重点关注家庭对 CNS 感染的临床影响和巨细胞病毒的影响。
研究结果显示，分析的样本中有 7.5%检测出 HHV 阳性，其中人类巨细胞病毒（HCMV）和 EBV 最为常见。HHV 与脑炎和脑膜炎等神经疾病之间存在显著关联，尤其是在 HIV/AIDS 患者（PLWHA）中，突出了这些病毒的机会性。该研究强调了 CSF 分析在诊断 CNS 感染中的重要性，以及由于 HIV 患者免疫功能低下，管理这些感染的复杂性。
结果强调了需要针对免疫功能低下个体的 CNS 感染采取综合诊断方法和定制治疗策略。该研究呼吁持续进行研究并推进临床实践，以改善 CNS 感染患者的治疗效果，特别是由 HHV 引起的感染。
