Botany and Microbiology Department, Faculty of Science, Damietta University, Damietta 34517, Egypt.
Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)/Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA/CSIC), Pozuelo de Alarcón, 28223 Madrid, Spain.
Viruses. 2024 Sep 18;16(9):1483. doi: 10.3390/v16091483.
Mycoviruses are highly genetically diverse and can significantly change their fungal host's phenotype, yet they are generally under-described in genotypic and biological studies. We propose as a model mycovirus system in which to develop a deeper understanding of mycovirus epidemiology including diversity, impact, and the associated cellular biology of the host and virus interaction. Over 100 mycoviruses have been described in this fungal host. is an ideal model fungus for mycovirology as it has highly tractable characteristics-it is easy to culture, has a worldwide distribution, infects a wide range of host plants, can be transformed and gene-edited, and has an existing depth of biological resources including annotated genomes, transcriptomes, and isolates with gene knockouts. Focusing on a model system for mycoviruses will enable the research community to address deep research questions that cannot be answered in a non-systematic manner. Since is a major plant pathogen, new insights may have immediate utility as well as creating new knowledge that complements and extends the knowledge of mycovirus interactions in other fungi, alone or with their respective plant hosts. In this review, we set out some of the critical steps required to develop as a model mycovirus system and how this may be used in the future.
真菌病毒具有高度的遗传多样性，能够显著改变其真菌宿主的表型，但在基因型和生物学研究中通常描述不足。我们提出将 作为一个模型真菌病毒系统，以深入了解真菌病毒的流行病学，包括多样性、影响以及宿主和病毒相互作用的相关细胞生物学。在这个真菌宿主中已经描述了超过 100 种真菌病毒。 是真菌病毒学的理想模型真菌，因为它具有高度可操作性的特点——易于培养，分布广泛，感染范围广泛的宿主植物，可转化和基因编辑，并且具有现有的生物资源深度，包括注释基因组、转录组和基因敲除的分离物。专注于真菌病毒的模型系统将使研究界能够解决无法以非系统方式回答的深层次研究问题。由于 是一种主要的植物病原体，新的见解可能具有直接的实用性，同时也创造了新知识，补充和扩展了其他真菌中真菌病毒相互作用的知识，无论是单独作用还是与各自的植物宿主一起作用。在这篇综述中，我们提出了将 发展为模型真菌病毒系统所需的一些关键步骤，以及未来如何使用该系统。
