Janská Tereza, Sakmár Michal, Štíbr Matěj, Vlk Martin, Kozempel Ján
Department of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Břehová 7, 11519 Prague 1, Czech Republic.
ACS Omega. 2024 Sep 12;9(38):39297-39306. doi: 10.1021/acsomega.4c04145. eCollection 2024 Sep 24.
The utilization of nanomaterials in biomedical applications has surged in recent years; yet, the transition from research to practical implementation remains a great challenge. However, a promising area of research has emerged with the integration of nanomaterials with diagnostic and therapeutic radionuclides. In this Review, we elucidate the motivations behind selecting metal oxide- and phosphate-based nanomaterials in conjunction with these radionuclides, while addressing its issues and limitations. Various metal oxide- and phosphate-based nanoparticles, exhibiting low toxicity and high tolerability, have been proposed for diverse biomedical applications, ranging from bone substitutes to drug delivery systems and controlled release vectors for pharmaceuticals, including radionuclides for nuclear medicine imaging and therapy. Moreover, the potential synergistic effects of multimodal combinational therapies, integrating chemotherapeutics, immunomodulators, or hyperthermia, underscore the versatility of these nanoconstructs. Our comprehensive exploration includes the underlying principles of radiolabeling strategies, the pivotal attributes of nanomaterial platforms, and their applications. Through this perspective, we present the potential of nanotechnology-enabled nuclear medicine. Furthermore, we discuss the potential systemic and local applications of these nanoconstructs, considering their and characteristics, as well as their physicochemical properties.
近年来，纳米材料在生物医学应用中的使用量激增；然而，从研究到实际应用的转变仍然是一个巨大的挑战。不过，随着纳米材料与诊断和治疗用放射性核素的结合，一个很有前景的研究领域已经出现。在这篇综述中，我们阐明了选择金属氧化物基和磷酸盐基纳米材料与这些放射性核素结合的背后动机，同时探讨了其问题和局限性。各种金属氧化物基和磷酸盐基纳米颗粒具有低毒性和高耐受性，已被提议用于多种生物医学应用，从骨替代物到药物递送系统以及药物（包括用于核医学成像和治疗的放射性核素）的控释载体。此外，整合化疗药物、免疫调节剂或热疗的多模态联合疗法的潜在协同效应，凸显了这些纳米结构的多功能性。我们的全面探索包括放射性标记策略的基本原理、纳米材料平台的关键属性及其应用。通过这个视角，我们展示了纳米技术支持的核医学的潜力。此外，我们讨论了这些纳米结构的潜在全身和局部应用，考虑到它们的……特性以及它们的物理化学性质。 （注：原文中“considering their and characteristics”部分内容缺失）
