Yadav Paramjeet, Singh Shiwani, Jaiswal Sheetal, Kumar Rajesh
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, UP, India.
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, UP, India.
Int J Biol Macromol. 2024 Nov;280(Pt 4):136126. doi: 10.1016/j.ijbiomac.2024.136126. Epub 2024 Sep 28.
This review centers on the synthesis and characterization of both natural and synthetic hydrogels, highlighting their diverse applications across various fields. We will delve into the evolution of hydrogels, focusing on the importance of polysaccharide-based and synthetic variants, which have been particularly chosen for 3D spheroid development in cancer research and drug delivery. A detailed background on the research and specific methodologies, including the in-situ free radical polymerization used for synthesizing these hydrogels, will be extensively discussed. Additionally, the review will explore various applications of these hydrogels, such as their self-healing properties, swelling ratios, pH responsiveness, and cell viability. A comprehensive literature review will support this investigation. Ultimately, this review aims to clearly outline the objectives and significance of hydrogel synthesis and their applications.
本综述聚焦于天然和合成水凝胶的合成与表征，突出其在各个领域的多样应用。我们将深入探讨水凝胶的发展历程，重点关注多糖基和合成变体的重要性，这些变体在癌症研究和药物递送的3D球体发育中被特别选用。将广泛讨论研究的详细背景和具体方法，包括用于合成这些水凝胶的原位自由基聚合。此外，本综述还将探索这些水凝胶的各种应用，如它们的自愈特性、溶胀率、pH响应性和细胞活力。全面的文献综述将支持这一研究。最终，本综述旨在清晰地勾勒出水凝胶合成及其应用的目标和意义。
