• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

果蝇全脑连接组的网络统计

Network statistics of the whole-brain connectome of Drosophila.

作者信息

Lin Albert, Yang Runzhe, Dorkenwald Sven, Matsliah Arie, Sterling Amy R, Schlegel Philipp, Yu Szi-Chieh, McKellar Claire E, Costa Marta, Eichler Katharina, Bates Alexander Shakeel, Eckstein Nils, Funke Jan, Jefferis Gregory S X E, Murthy Mala

机构信息

Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.

Center for the Physics of Biological Function, Princeton University, Princeton, NJ, USA.

出版信息

Nature. 2024 Oct;634(8032):153-165. doi: 10.1038/s41586-024-07968-y. Epub 2024 Oct 2.

DOI:10.1038/s41586-024-07968-y
PMID:39358527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11446825/
Abstract

Brains comprise complex networks of neurons and connections, similar to the nodes and edges of artificial networks. Network analysis applied to the wiring diagrams of brains can offer insights into how they support computations and regulate the flow of information underlying perception and behaviour. The completion of the first whole-brain connectome of an adult fly, containing over 130,000 neurons and millions of synaptic connections, offers an opportunity to analyse the statistical properties and topological features of a complete brain. Here we computed the prevalence of two- and three-node motifs, examined their strengths, related this information to both neurotransmitter composition and cell type annotations, and compared these metrics with wiring diagrams of other animals. We found that the network of the fly brain displays rich-club organization, with a large population (30% of the connectome) of highly connected neurons. We identified subsets of rich-club neurons that may serve as integrators or broadcasters of signals. Finally, we examined subnetworks based on 78 anatomically defined brain regions or neuropils. These data products are shared within the FlyWire Codex ( https://codex.flywire.ai ) and should serve as a foundation for models and experiments exploring the relationship between neural activity and anatomical structure.

摘要

大脑由神经元和连接组成的复杂网络构成，类似于人工网络的节点和边。应用于大脑布线图的网络分析能够深入了解大脑如何支持计算以及调节感知和行为背后的信息流。成年果蝇首个全脑连接组的完成，包含超过13万个神经元和数百万个突触连接，为分析完整大脑的统计特性和拓扑特征提供了契机。在此，我们计算了两节点和三节点基序的发生率，检查了它们的强度，将这些信息与神经递质组成和细胞类型注释相关联，并将这些指标与其他动物的布线图进行了比较。我们发现果蝇大脑网络呈现出富俱乐部组织，有大量（连接组的30%）高度连接的神经元。我们确定了富俱乐部神经元的子集，它们可能充当信号的整合者或传播者。最后，我们基于78个解剖学定义的脑区或神经纤维网检查了子网。这些数据产品在FlyWire Codex（https://codex.flywire.ai）中共享，应作为探索神经活动与解剖结构之间关系的模型和实验的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/0e803d41f6ad/41586_2024_7968_Fig14_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/216edf42cf75/41586_2024_7968_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/0390512bf6fc/41586_2024_7968_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/b6c247393ca3/41586_2024_7968_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/d71e9a74740a/41586_2024_7968_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/6486d34a6665/41586_2024_7968_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/4f3d8c8e4b39/41586_2024_7968_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/a4aa77e98f71/41586_2024_7968_Fig7_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/a25000c416a2/41586_2024_7968_Fig8_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/f34238ae3e42/41586_2024_7968_Fig9_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/b8a3063f7cef/41586_2024_7968_Fig10_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/b2408b5ccc38/41586_2024_7968_Fig11_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/fdaa185cc2d3/41586_2024_7968_Fig12_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/dca56da4c493/41586_2024_7968_Fig13_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/0e803d41f6ad/41586_2024_7968_Fig14_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/216edf42cf75/41586_2024_7968_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/0390512bf6fc/41586_2024_7968_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/b6c247393ca3/41586_2024_7968_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/d71e9a74740a/41586_2024_7968_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/6486d34a6665/41586_2024_7968_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/4f3d8c8e4b39/41586_2024_7968_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/a4aa77e98f71/41586_2024_7968_Fig7_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/a25000c416a2/41586_2024_7968_Fig8_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/f34238ae3e42/41586_2024_7968_Fig9_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/b8a3063f7cef/41586_2024_7968_Fig10_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/b2408b5ccc38/41586_2024_7968_Fig11_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/fdaa185cc2d3/41586_2024_7968_Fig12_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/dca56da4c493/41586_2024_7968_Fig13_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11446825/0e803d41f6ad/41586_2024_7968_Fig14_ESM.jpg

相似文献

1
Network statistics of the whole-brain connectome of Drosophila.果蝇全脑连接组的网络统计
Nature. 2024 Oct;634(8032):153-165. doi: 10.1038/s41586-024-07968-y. Epub 2024 Oct 2.
2
Network Statistics of the Whole-Brain Connectome of ..的全脑连接组的网络统计数据
bioRxiv. 2024 Feb 28:2023.07.29.551086. doi: 10.1101/2023.07.29.551086.
3
Neuronal wiring diagram of an adult brain.成人大脑的神经元连接图。
Nature. 2024 Oct;634(8032):124-138. doi: 10.1038/s41586-024-07558-y. Epub 2024 Oct 2.
4
A connectome and analysis of the adult central brain.一个成年中枢大脑的连接组和分析。
Elife. 2020 Sep 7;9:e57443. doi: 10.7554/eLife.57443.
5
Spatiotemporal ontogeny of brain wiring.大脑连接的时空发生。
Sci Adv. 2019 Jun 12;5(6):eaav9694. doi: 10.1126/sciadv.aav9694. eCollection 2019 Jun.
6
Predicting visual function by interpreting a neuronal wiring diagram.通过解读神经元接线图预测视觉功能。
Nature. 2024 Oct;634(8032):113-123. doi: 10.1038/s41586-024-07953-5. Epub 2024 Oct 2.
7
The fly connectome reveals a path to the effectome.果蝇连接体揭示了通向效应组的途径。
Nature. 2024 Oct;634(8032):201-209. doi: 10.1038/s41586-024-07982-0. Epub 2024 Oct 2.
8
The rich club of the C. elegans neuronal connectome.秀丽隐杆线虫神经元连接组的富裕俱乐部。
J Neurosci. 2013 Apr 10;33(15):6380-7. doi: 10.1523/JNEUROSCI.3784-12.2013.
9
Synaptic architecture of leg and wing premotor control networks in Drosophila.果蝇腿部和翅膀运动前控制网络的突触结构。
Nature. 2024 Jul;631(8020):369-377. doi: 10.1038/s41586-024-07600-z. Epub 2024 Jun 26.
10
Diverse Community Structures in the Neuronal-Level Connectome of the Drosophila Brain.果蝇大脑神经元水平连接组中的多样化社区结构。
Neuroinformatics. 2020 Apr;18(2):267-281. doi: 10.1007/s12021-019-09443-w.

引用本文的文献

1
SynAnno: Interactive Guided Proofreading of Synaptic Annotations.SynAnno：突触注释的交互式引导校对
bioRxiv. 2025 Aug 12:2025.08.09.669342. doi: 10.1101/2025.08.09.669342.
2
Distributed control circuits across a brain-and-cord connectome.遍布脑脊髓连接组的分布式控制电路。
bioRxiv. 2025 Aug 2:2025.07.31.667571. doi: 10.1101/2025.07.31.667571.
3
A multisynaptic spiking neuron for simultaneously encoding spatiotemporal dynamics.一种用于同时编码时空动态的多突触发放神经元。

本文引用的文献

1
Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster.在果蝇的突触部位从电子显微镜图像中对神经递质进行分类。
Cell. 2024 May 9;187(10):2574-2594.e23. doi: 10.1016/j.cell.2024.03.016.
2
Cyclic structure with cellular precision in a vertebrate sensorimotor neural circuit.脊椎动物感觉运动神经回路中具有细胞精度的循环结构。
Curr Biol. 2023 Jun 5;33(11):2340-2349.e3. doi: 10.1016/j.cub.2023.05.010. Epub 2023 May 25.
3
The connectome of an insect brain.昆虫大脑的连接组图谱。
Nat Commun. 2025 Aug 4;16(1):7155. doi: 10.1038/s41467-025-62251-6.
4
Neural circuit mechanisms for steering control in walking .行走中转向控制的神经回路机制
Elife. 2025 Jul 21;13:RP102230. doi: 10.7554/eLife.102230.
5
Sexually-dimorphic neurons in the whole-brain connectome.全脑连接组中的性二态神经元。
Res Sq. 2025 Jun 26:rs.3.rs-6881911. doi: 10.21203/rs.3.rs-6881911/v1.
6
Sexually-dimorphic neurons in the whole-brain connectome.全脑连接组中的性二态神经元。
bioRxiv. 2025 Jun 14:2025.06.10.658788. doi: 10.1101/2025.06.10.658788.
7
A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain.用于幼体斑马鱼大脑神经编目和神经回路剖析的连接体资源。
bioRxiv. 2025 Jun 15:2025.06.10.658982. doi: 10.1101/2025.06.10.658982.
8
High-speed whole-brain imaging in .中的高速全脑成像
bioRxiv. 2025 Jun 19:2025.06.18.660371. doi: 10.1101/2025.06.18.660371.
9
A neuromorphic model of active vision shows how spatiotemporal encoding in lobula neurons can aid pattern recognition in bees.一种主动视觉的神经形态模型展示了小叶神经元中的时空编码如何帮助蜜蜂进行模式识别。
Elife. 2025 Jul 1;14:e89929. doi: 10.7554/eLife.89929.
10
The Drosophila adult brain: short overview of structure, function, and resources Graphical Review Paper.果蝇成体大脑：结构、功能及资源概述 图形综述论文
Curr Res Insect Sci. 2025 May 15;7:100113. doi: 10.1016/j.cris.2025.100113. eCollection 2025.
Science. 2023 Mar 10;379(6636):eadd9330. doi: 10.1126/science.add9330.
4
Nonspiking Interneurons in the Antennal Lobe Exhibit Spatially Restricted Activity.触角叶中的非放电中间神经元表现出空间限制的活动。
eNeuro. 2023 Jan 25;10(1). doi: 10.1523/ENEURO.0109-22.2022. Print 2023 Jan.
5
Neural network organization for courtship-song feature detection in Drosophila.果蝇求偶歌曲特征检测的神经网络组织。
Curr Biol. 2022 Aug 8;32(15):3317-3333.e7. doi: 10.1016/j.cub.2022.06.019. Epub 2022 Jul 5.
6
The impact of neuron morphology on cortical network architecture.神经元形态对皮质网络结构的影响。
Cell Rep. 2022 Apr 12;39(2):110677. doi: 10.1016/j.celrep.2022.110677.
7
Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity.新皮层的重建：细胞器、区室、细胞、回路和活动。
Cell. 2022 Mar 17;185(6):1082-1100.e24. doi: 10.1016/j.cell.2022.01.023. Epub 2022 Feb 24.
8
FlyWire: online community for whole-brain connectomics.FlyWire：全脑连接组学在线社区。
Nat Methods. 2022 Jan;19(1):119-128. doi: 10.1038/s41592-021-01330-0. Epub 2021 Dec 23.
9
A connectome of the central complex reveals network motifs suitable for flexible navigation and context-dependent action selection.中央复合体的连接组揭示了适用于灵活导航和上下文依赖动作选择的网络基序。
Elife. 2021 Oct 26;10:e66039. doi: 10.7554/eLife.66039.
10
Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion.运动过程中动态皮质网络的宽场钙成像。
Cereb Cortex. 2022 Jun 7;32(12):2668-2687. doi: 10.1093/cercor/bhab373.