Mizoi K, Olca M, Fujimoto S, Abiko H, Suzuki J
No To Shinkei. 1984 Nov;36(11):1089-93.
Using the "canine model of complete ischemic brain regulated with a perfusion method" in which it is possible to control the degree of blood flow to a cerebral hemisphere via a perfusion pump, the protective effects of nizofenone against cerebral ischemia was investigated. After pre-treatment with nizofenone, blood flow was reduced via the pump to 1/10 of the normal state and 1 hour later, return to the normal state was allowed. Subsequent changes in EEG activity were observed and the effect of nizofenone evaluated. In the control group, no recovery of EEG was seen following recirculation, but in the group treated with nizofenone, gradual emergence of slow waves was observed. And the degree of recovery of EEG was better in the group administered a large dosage than in those given a low dosage. Our study suggested that within the dose ranges tested, nizofenone ameliorated ischemic brain damage in a dose dependent fashion. But the application of this experimental results to the human clinical situation requires that particular note should be paid to the dangers of transient fall of blood pressure at higher dosages.
使用“通过灌注方法调节的完全缺血性脑犬模型”，该模型可以通过灌注泵控制大脑半球的血流程度，研究了尼唑苯酮对脑缺血的保护作用。在用尼唑苯酮预处理后，通过泵将血流减少至正常状态的1/10，1小时后，使其恢复到正常状态。观察脑电图（EEG）活动的后续变化并评估尼唑苯酮的效果。在对照组中，再灌注后未见EEG恢复，但在尼唑苯酮治疗组中，观察到慢波逐渐出现。并且大剂量给药组的EEG恢复程度优于小剂量给药组。我们的研究表明，在所测试的剂量范围内，尼唑苯酮以剂量依赖性方式改善缺血性脑损伤。但是将该实验结果应用于人类临床情况时，需要特别注意高剂量时血压短暂下降的风险。
