Università Vita-Salute San Raffaele, Milan, Italy.
https://ror.org/039zxt351 IRCCS Ospedale San Raffaele, Division of Genetics and Cell Biology, Milan, Italy.
Life Sci Alliance. 2024 Oct 4;7(12). doi: 10.26508/lsa.202402627. Print 2024 Dec.
Upon hormonal stimulation, uterine endometrial stromal cells undergo a dramatic morpho-functional metamorphosis that allows them to secrete large amounts of matrix proteins, cytokines, and growth factors. This step, known as decidualization, is crucial for embryo implantation. We previously demonstrated how the secretory pathway is remodelled during this process. Here we show that hormonal stimulation rapidly induces the expression of many mitochondrial genes, encoded in both the mitochondrial and the nuclear genomes. Altogether, the mitochondrial network quadruples its size and establishes more contacts with the ER. This new organization results in the increased respiratory capacity of decidualized cells. These findings reveal how achieving an efficient secretory phenotype requires a radical metabolic rewiring.
在激素刺激下，子宫子宫内膜基质细胞经历了剧烈的形态和功能转变，使它们能够分泌大量的基质蛋白、细胞因子和生长因子。这一步骤称为蜕膜化，对胚胎着床至关重要。我们之前已经证明了在这个过程中分泌途径是如何重塑的。在这里，我们表明激素刺激会迅速诱导许多线粒体基因的表达，这些基因既存在于线粒体基因组中，也存在于核基因组中。总的来说，线粒体网络的大小增加了四倍，并与内质网建立了更多的联系。这种新的组织导致了蜕膜化细胞呼吸能力的增加。这些发现揭示了如何实现有效的分泌表型需要彻底的代谢重编程。
