Kuitunen Ilari
Institute of Clinical Medicine and Kuopio Pediatric Research Unit, University of Eastern Finland, Kuopio, Finland.
Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
Acta Paediatr. 2025 Jan;114(1):51-55. doi: 10.1111/apa.17438. Epub 2024 Oct 5.
To characterise typical practices in conducting and reporting umbrella reviews in paediatrics.
PubMed database was searched for umbrella reviews focusing on children (0-18 years) published from 1 January 2020 to 15 June 2024, regardless of the speciality. The included studies were assessed for reporting practices, result summarisation and critical appraisal methods.
Ninety-nine eligible umbrella reviews were included, of which 49 focused on interventions and 50 focused on epidemiology. The median number of included reviews in the umbrella reviews was 18 (range = 3-302), and statistical synthesis was performed in 32 studies. The most frequently used tool for critical appraisal of the included reviews was the updated Assessing the Methodological Quality of Systematic Reviews (AMSTAR-2) tool (n = 56); the original AMSTAR-1 tool was used in seven reviews, and the Risk of Bias in Systematic Reviews tool was used in 12 reviews. Evidence certainty was assessed using the Grading of Recommendations Assessment, Development and Evaluation framework in 14 reviews and by the Ioannidis criteria in 18 reviews.
Umbrella reviews have heterogeneous characteristics in terms of reporting practices. Greater adherence to guidelines on conducting and reporting umbrella reviews is needed, particularly for improving critical appraisal methods.
描述儿科领域开展和报告综合性循证综述的典型做法。
在PubMed数据库中检索2020年1月1日至2024年6月15日发表的聚焦于儿童（0至18岁）的综合性循证综述，不限专业。对纳入研究的报告做法、结果总结和批判性评价方法进行评估。
纳入99篇符合条件的综合性循证综述，其中49篇聚焦于干预措施，50篇聚焦于流行病学。综合性循证综述中纳入综述的中位数为18篇（范围=3至302篇），32项研究进行了统计合成。对纳入综述进行批判性评价最常用的工具是更新后的《系统评价方法学质量评估》（AMSTAR-2）工具（n=56）；7篇综述使用了原始的AMSTAR-1工具，12篇综述使用了《系统评价中的偏倚风险》工具。14篇综述使用《推荐分级的评估、制定与评价》框架评估证据确定性，18篇综述使用Ioannidis标准评估。
综合性循证综述在报告做法方面具有异质性特征。需要更严格地遵循开展和报告综合性循证综述的指南，特别是在改进批判性评价方法方面。
