Shaheen Nour, Shaheen Ahmed, Osama Mahmoud, Nashwan Abdulqadir J, Bharmauria Vishal, Flouty Oliver
Alexandria University, Alexandria Faculty of Medicine, Alexandria, Egypt.
Department of Neurosurgery, Nasser Institute for Research and Treatment, Cairo, Egypt.
NPJ Parkinsons Dis. 2024 Oct 5;10(1):186. doi: 10.1038/s41531-024-00791-2.
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by binding to target messenger RNA (mRNA) molecules and promoting their degradation or blocking their translation. Parkinson's disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra. There is increasing evidence to suggest that miRNAs play a role in the pathogenesis of PD. Studies have identified several miRNAs that are dysregulated in the brains of PD patients, and animal models of the disease. MiRNA expression dysregulation contributes to the onset and progression of PD by modulating neuroinflammation, oxidative stress, and protein aggregation genes. Moreover, miRNAs have emerged as potential therapeutic targets for PD. This review elucidates the changes in miRNA expression profiles associated with PD, emphasising their potential as diagnostic biomarkers and therapeutic targets, and detailing specific miRNAs implicated in PD and their downstream targets. Integrated Insights into miRNA Function, Microglial Activation, Diagnostic, and Treatment Prospects in PD Note: This figure is an original figure created by the authors.
微小RNA（miRNA）是一类小的非编码RNA分子，它们通过与靶信使RNA（mRNA）分子结合并促进其降解或阻断其翻译来调节基因表达。帕金森病（PD）是一种由黑质中多巴胺能神经元丧失引起的神经退行性疾病。越来越多的证据表明，miRNA在PD的发病机制中起作用。研究已经鉴定出几种在PD患者大脑和该疾病的动物模型中表达失调的miRNA。miRNA表达失调通过调节神经炎症、氧化应激和蛋白质聚集基因，促进PD的发生和发展。此外，miRNA已成为PD的潜在治疗靶点。这篇综述阐述了与PD相关的miRNA表达谱的变化，强调了它们作为诊断生物标志物和治疗靶点的潜力，并详细介绍了与PD相关的特定miRNA及其下游靶点。对PD中miRNA功能、小胶质细胞激活、诊断和治疗前景的综合见解 注：此图为作者原创。
