Winkelmayer Lisa, Rathammer Krista, Richter Susanne, Requat Theres, Matt Monika, Ljuhar Davul, Jäger Philippe, Kernmauner Friedrich, Naemi Seyed, Mansfeld Michael Dieter, Duscher Georg G
Austrian Agency for Health and Food Safety, Vienna, Austria.
Braincon GmbH & Co KG, Vienna, Austria.
Phage (New Rochelle). 2024 Sep 16;5(3):126-129. doi: 10.1089/phage.2023.0037. eCollection 2024 Sep.
Phages are known as a promising method to combat antimicrobial resistance (AMR) in the human and veterinary sector. Use of phage aerosols enormously increases the application field, although the impact on the infectivity of phages during nebulization needs to be evaluated. In this study was treated on plates and chicken skin with nebulized phage particles of the type, identified by transmission electron microscopy, using a commercial nebulizer primarily used for HO disinfection. The reduction of bacterial number by aerosol applied phage particles was evaluated. It could clearly be shown that the phage particles were able to infect after being nebulized using ultrasound technology. Further studies on other types of phages as well as other conditions must be performed to standardize the aerosolic application of phages.
噬菌体被认为是一种在人类和兽医领域对抗抗菌药物耐药性（AMR）的有前景的方法。使用噬菌体气溶胶极大地扩展了应用领域，尽管雾化过程中对噬菌体感染性的影响需要评估。在本研究中，使用主要用于过氧化氢消毒的商用雾化器，对通过透射电子显微镜鉴定的特定类型的雾化噬菌体颗粒在平板和鸡皮肤上进行处理。评估了气溶胶应用的噬菌体颗粒对细菌数量的减少情况。结果清楚地表明，使用超声技术雾化后，噬菌体颗粒能够感染（细菌）。必须对其他类型的噬菌体以及其他条件进行进一步研究，以规范噬菌体的气溶胶应用。
