Durr Hannah A, Leipzig Nic D
Department of Integrated Biosciences, University of Akron Ohio 44325 USA.
Department of Chemical, Biomolecular, and Corrosion Engineering, University of Akron Ohio 44325 USA
Mater Adv. 2023 Jan 31;4(5):1249-1257. doi: 10.1039/d2ma00980c. eCollection 2023 Mar 6.
Having co-evolved with bacteria over hundreds of millions of years, bacteriophage are effective killers of specific bacterial hosts. Therefore, phage therapies for infection are a promising treatment avenue, can provide a solution for antibiotic resistant bacterial infections, and have specified targeting of infectious bacteria while allowing the natural microbiome to survive which systemic antibiotics often wipe out. Many phages have well studied genomes that can be modified to change target, widen target range, or change mode of action of killing bacterial hosts. Phage delivery can also be designed to increase efficacy of treatment, including encapsulation and delivery biopolymers. Increased research into phage potential for therapies can allow new avenues to develop to treat a larger range of infections.
在数亿年的时间里与细菌共同进化，噬菌体是特定细菌宿主的有效杀手。因此，针对感染的噬菌体疗法是一条有前景的治疗途径，可为耐药细菌感染提供解决方案，能够特异性靶向感染细菌，同时让天然微生物群存活下来，而全身使用的抗生素常常会将其消灭。许多噬菌体的基因组已得到充分研究，可以进行改造以改变靶点、扩大靶点范围或改变杀死细菌宿主的作用方式。噬菌体递送也可以设计成提高治疗效果，包括封装和递送生物聚合物。加强对噬菌体治疗潜力的研究可以开辟新途径，以治疗更多类型的感染。
