Milani Amin Salem, Hadinia Faezeh, Rezaei Yashar, Soroush Barhaghi Mohammad Hossein, Attari Kamal, Nouroloyouni Ahmad
Endodontic Department, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Dental Biomaterials, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Biomater. 2024 Jul 23;2024:4190647. doi: 10.1155/2024/4190647. eCollection 2024.
This study aimed to assess the effect of addition of bioactive glass (BG) on the setting time and antibacterial activity of mineral trioxide aggregate (MTA) against Enterococcus faecalis (E. faecalis).
In this in vitro study, BG was synthesized by the sol-gel technique and added to MTA powder in certain ratios. Three groups of specimens were fabricated from pure MTA, MTA mixed with 10wt% BG, and MTA mixed with 20wt% BG. The setting time of specimens was measured according to ISO9917-2007. Direct contact test was used to assess the antimicrobial activity of the three groups against E. faecalis. Data were analyzed by repeated measures ANOVA (alpha = 0.05).
Addition of BG (in both concentrations) to MTA decreased its setting time and improved its antibacterial activity against E. faecalis ( < 0.05). By an increase in concentration of BG (20%), the antimicrobial activity further improved ( < 0.05).
Addition of BG to MTA in 10wt% and 20wt% concentrations decreased its setting time and improved its antibacterial activity against E. faecalis.
本研究旨在评估添加生物活性玻璃（BG）对三氧化矿物凝聚体（MTA）凝固时间及抗粪肠球菌抗菌活性的影响。
在本体外研究中，采用溶胶 - 凝胶技术合成BG，并按一定比例添加到MTA粉末中。制备三组试件，分别为纯MTA、混合10wt% BG的MTA以及混合20wt% BG的MTA。根据ISO9917 - 2007测量试件的凝固时间。采用直接接触试验评估三组对粪肠球菌的抗菌活性。数据采用重复测量方差分析（α = 0.05）进行分析。
向MTA中添加BG（两种浓度）均缩短了其凝固时间，并提高了其对粪肠球菌的抗菌活性（P < 0.05）。随着BG浓度增加至20%，抗菌活性进一步提高（P < 0.05）。
向MTA中添加10wt%和20wt%浓度的BG可缩短其凝固时间，并提高其对粪肠球菌的抗菌活性。
