Wang Ping, Huang Jianping, Wei Jingjing, Yu Qianhengyuan, Li Guanglin, Yu Bin, Yang Lin, Liu Zhiyuan
Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, China.
Biomedical Sensing Engineering and Technology Research Center, Shandong University, Jinan, 25000, China.
Heliyon. 2024 Sep 18;10(18):e38041. doi: 10.1016/j.heliyon.2024.e38041. eCollection 2024 Sep 30.
Currently, prosthesis users rely on visual cues to control their prosthesis. One reason for this is that prostheses cannot provide users with proprioceptive functional signals. For this reason, we propose an agonist-antagonist myoneural interface (AMI) surgery. We examined how this surgery affects the restoration of motor function and proprioceptive reconstruction in the hind limb of Sprague-Dawley rats. The procedure entails grafting the soleus muscle, suturing the two tendon ends of the soleus muscle, and anastomosing the tibial and common peroneal nerves to the soleus muscle. We found that, following surgery, AMI rats exhibited improved neurological repair, shorter walking swings, braking, propulsion, and stance times, and greater compound action potentials than control rats. This means that in rats with neurological impairment of the hind limb, the proposed AMI surgical method significantly improves postoperative walking stability and muscle synergy. AMI surgery may become an option for regaining proprioception in the lost limb.
目前，假肢使用者依靠视觉线索来控制他们的假肢。原因之一是假肢无法向使用者提供本体感觉功能信号。因此，我们提出了一种主动肌-拮抗肌肌神经接口（AMI）手术。我们研究了该手术如何影响Sprague-Dawley大鼠后肢运动功能的恢复和本体感觉重建。该手术包括移植比目鱼肌、缝合比目鱼肌的两个肌腱末端，以及将胫神经和腓总神经与比目鱼肌吻合。我们发现，手术后，AMI大鼠的神经修复得到改善，行走摆动、制动、推进和站立时间缩短，复合动作电位比对照大鼠更大。这意味着，对于后肢神经受损的大鼠，所提出的AMI手术方法显著提高了术后行走稳定性和肌肉协同作用。AMI手术可能成为恢复失肢本体感觉的一种选择。
