Department of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
J Mater Chem B. 2024 Oct 30;12(42):10757-10769. doi: 10.1039/d4tb01860e.
A need to enhance the precision and specificity of therapeutic nanocarriers inspires the development of advanced nanomaterials capable of sensing and responding to disease-related cues. Self-assembled peptides offer a promising nanocarrier platform with versatile use to create precisely defined nanoscale materials. Disease-relevant cues can range from large biomolecules, such as enzymes, to ubiquitous small molecules with varying concentrations in healthy diseased states. Notably, pH changes (, H concentration), redox species (, HO), and glucose levels are significant spatial and/or temporal indicators of therapeutic need. Self-assembled peptides respond to these cues by altering their solubility, modulating electrostatic interactions, or facilitating chemical transformations through dynamic or labile bonds. This review explores the design and construction of therapeutic nanocarriers using self-assembled peptides, focusing on how peptide sequence engineering along with the inclusion of non-peptidic components can link the assembly state of these nanocarriers to the presence of disease-relevant small molecules.
需要提高治疗性纳米载体的精度和特异性，这激发了先进纳米材料的发展，这些材料能够感知和响应与疾病相关的线索。自组装肽提供了一个有前途的纳米载体平台，具有多种用途，可以精确地定义纳米级材料。与疾病相关的线索范围很广，从大的生物分子（如酶）到在健康和疾病状态下浓度不同的普遍小分子。值得注意的是，pH 值变化（氢离子浓度）、氧化还原物种（活性氧）和葡萄糖水平是治疗需求的重要空间和/或时间指标。自组装肽通过改变其溶解度、调节静电相互作用，或通过动态或不稳定键促进化学转化来响应这些线索。本综述探讨了使用自组装肽设计和构建治疗性纳米载体的方法，重点介绍了如何通过肽序列工程以及包含非肽成分，将这些纳米载体的组装状态与疾病相关小分子的存在联系起来。
