Department of Obstetrics, Xingtai People's Hospital, Xingtai, China.
Department of Operating Room, Xingtai People's Hospital, Xingtai, China.
Braz J Med Biol Res. 2024 Oct 7;57:e13253. doi: 10.1590/1414-431X2024e13253. eCollection 2024.
Jun N-terminal kinase pathway-associated phosphatase (JKAP) regulates CD4+ T-cell differentiation and immunity, which are linked to mental disorders. This study aimed to explore the relationships between JKAP and T helper 17 (Th17)/regulatory T (Treg) ratio, as well as their associations with anxiety and depression in postpartum women. Serum JKAP were measured by enzyme-linked immunosorbent assay and blood Th17 and Treg cells were measured by flow cytometry in 250 postpartum women. Anxiety and depression were evaluated by the 6-item State-Trait Anxiety Inventory (STAI6) and Edinburgh Postnatal Depression Scale (EPDS). Anxiety and depression rates were 22.0 and 28.4%, respectively, among postpartum women. Notably, JKAP was negatively associated with the STAI6 (P=0.002) and EPDS scores (P<0.001) in postpartum women and was lower in postpartum women with anxiety (P=0.023) or depression (P=0.002) than in those without. Moreover, JKAP was inversely related to Th17 cells and Th17/Treg ratio but positively correlated with Treg cells in postpartum women (all P<0.001). Interestingly, Th17 cells and Th17/Treg ratio were both positively associated with STAI6 and EPDS scores in postpartum women (all P<0.001). Furthermore, Th17 cells and Th17/Treg ratio were lower in postpartum women with anxiety or depression than in those without (all P<0.01). Nevertheless, Treg cells were not linked to anxiety or depression in postpartum women. JKAP was negatively associated with Th17 cells and Th17/Treg ratio; moreover, they all related to anxiety and depression in postpartum women, indicating that JKAP may be involved in postpartum anxiety and depression via interactions with Th17 cells.
Jun N-末端激酶通路相关磷酸酶（JKAP）调节 CD4+T 细胞分化和免疫，与精神障碍有关。本研究旨在探讨 JKAP 与辅助性 T 细胞 17（Th17）/调节性 T（Treg）比值的关系，及其与产后妇女焦虑和抑郁的关系。采用酶联免疫吸附试验测定 250 例产后妇女血清 JKAP，流式细胞术检测血 Th17 和 Treg 细胞。采用状态特质焦虑量表（STAI6）和爱丁堡产后抑郁量表（EPDS）评估焦虑和抑郁。产后妇女焦虑和抑郁发生率分别为 22.0%和 28.4%。值得注意的是，JKAP 与产后妇女的 STAI6（P=0.002）和 EPDS 评分（P<0.001）呈负相关，且焦虑（P=0.023）或抑郁（P=0.002）的产后妇女 JKAP 水平低于无焦虑或抑郁的产后妇女。此外，JKAP 与产后妇女 Th17 细胞和 Th17/Treg 比值呈负相关，与 Treg 细胞呈正相关（均 P<0.001）。有趣的是，Th17 细胞和 Th17/Treg 比值与产后妇女的 STAI6 和 EPDS 评分均呈正相关（均 P<0.001）。此外，焦虑或抑郁的产后妇女 Th17 细胞和 Th17/Treg 比值均低于无焦虑或抑郁的产后妇女（均 P<0.01）。然而，Treg 细胞与产后妇女的焦虑或抑郁无关。JKAP 与 Th17 细胞和 Th17/Treg 比值呈负相关；此外，它们都与产后妇女的焦虑和抑郁有关，表明 JKAP 可能通过与 Th17 细胞的相互作用参与产后焦虑和抑郁。
