Akimbekov Nuraly S, Coban Seval Ozkan, Atfi Azeddine, Razzaque Mohammed S
Scientific-Practical Center, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Sustainability of Ecology and Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Front Nutr. 2024 Sep 25;11:1458700. doi: 10.3389/fnut.2024.1458700. eCollection 2024.
Magnesium plays an essential role in glucose utilization and insulin signaling. Recent advances have revealed a greater prevalence of hypomagnesemia in general, and low intracellular magnesium levels in individuals with diabetes contribute to β-cell dysfunction and insulin resistance. This article describes the documented effects of magnesium on various aspects of β-cells and glucose homeostasis. Studies have demonstrated that magnesium deficiency is associated with reduced pancreatic β-cell activity and increased insulin resistance in patients with type 2 diabetes. Additionally, magnesium is involved in many cellular events, including energy homeostasis, protein synthesis, and DNA stability. Furthermore, magnesium is critical for proper glucose utilization and insulin signaling, and magnesium deficiency can lead to the dysregulation of ATP-sensitive potassium (KATP) channels in pancreatic β-cells, impairing insulin secretion. Therefore, maintaining adequate magnesium levels is crucial for maintaining overall health and preventing of metabolic disorders such as type 2 diabetes.
镁在葡萄糖利用和胰岛素信号传导中起着至关重要的作用。最近的研究进展表明，一般人群中低镁血症的患病率更高，糖尿病患者细胞内镁水平低会导致β细胞功能障碍和胰岛素抵抗。本文描述了镁对β细胞和葡萄糖稳态各个方面的已记录影响。研究表明，镁缺乏与2型糖尿病患者胰腺β细胞活性降低和胰岛素抵抗增加有关。此外，镁参与许多细胞活动，包括能量稳态、蛋白质合成和DNA稳定性。此外，镁对于正常的葡萄糖利用和胰岛素信号传导至关重要，镁缺乏会导致胰腺β细胞中ATP敏感性钾（KATP）通道失调，损害胰岛素分泌。因此，维持足够的镁水平对于维持整体健康和预防2型糖尿病等代谢紊乱至关重要。
