Chukwu C C
Int J Zoonoses. 1985 Sep;12(3):196-202.
The serological response of heifers to injection with Brucella abortus strain 19 vaccine and simultaneous administration of levamisole hydrochloride were compared with those of heifers inoculated with Brucella abortus strain 19 vaccine alone. The Rose Bengal, serum agglutination, complement fixation and Coombs' antibovine globulin tests were used to measure the humoral responses for a period of sixteen weeks after vaccination. The results indicated that antibody titres in the heifers injected with levamisole and the vaccine were moderately elevated. It was suggested that the heightened antibody titres were possibly mediated through helper T-cells and macrophages. The significance of using levamisole as an adjuvant with Brucella abortus strain 19 vaccine in cattle is briefly discussed.
将注射布鲁氏菌流产菌株19疫苗并同时给予盐酸左旋咪唑的小母牛的血清学反应，与仅接种布鲁氏菌流产菌株19疫苗的小母牛的血清学反应进行了比较。采用玫瑰红、血清凝集、补体结合和库姆斯抗牛球蛋白试验，在接种疫苗后的16周内测定体液反应。结果表明，注射左旋咪唑和疫苗的小母牛的抗体滴度适度升高。有人认为，抗体滴度的升高可能是通过辅助性T细胞和巨噬细胞介导的。简要讨论了在牛中使用左旋咪唑作为布鲁氏菌流产菌株19疫苗佐剂的意义。
