Alton G G
Aust Vet J. 1978 Dec;54(12):551-7. doi: 10.1111/j.1751-0813.1978.tb02410.x.
Recent research in vaccination against bovine brucellosis has been directed towards reducing the serological response to vaccination and to developing serological tests better able to distinguish vaccinal titres from those resulting from field infection. In the case of strain 19 vaccination, developments such as reducing the dose of vaccine and improving serological tests have so reduced the serological response as to allow adult vaccination to be carried out in combination with eradiction by test and slaughter. B. abortus 45/20 vaccine is being increasingly used as a combined diagnostic aid and protective agent. Progress has been made in identifying antibodies produced in response to this vaccine.
近期针对牛布鲁氏菌病疫苗接种的研究致力于降低疫苗接种后的血清学反应，并开发出能更好地区分疫苗接种产生的滴度与野外感染产生的滴度的血清学检测方法。就19号菌株疫苗接种而言，诸如减少疫苗剂量和改进血清学检测等进展已大幅降低了血清学反应，从而使得成年牛的疫苗接种能够与通过检测和屠宰进行根除的措施相结合。流产布鲁氏菌45/20疫苗越来越多地被用作联合诊断辅助剂和保护剂。在鉴定针对该疫苗产生的抗体方面已取得进展。
