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Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein.

作者信息

O'Malley K, Mauron A, Barchas J D, Kedes L

出版信息

Mol Cell Biol. 1985 Dec;5(12):3476-83. doi: 10.1128/mcb.5.12.3476-3483.1985.

DOI:10.1128/mcb.5.12.3476-3483.1985
PMID:3939319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC369178/
Abstract

A nearly full-length cDNA clone isolated from the rat pheochromocytoma cell line, PC12, revealed extensive nucleotide sequence similarity between the rat cDNA and the Drosophila melanogaster hsp70 gene. The rat recombinant clone encodes a 71,000-dalton protein that is 70% identical with the dipteran hsp70 protein. Remarkably, a truncated segment of this cDNA clone was originally isolated by immunoreactivity with antisera raised to catecholamine-synthesizing enzymes, suggesting that this heat shock protein and these catecholamine enzymes shared antigenic determinants. The rat hsp70-related mRNA is responsible for the production of a constitutive hsp70 protein, because it is present in abundant amounts in various tissues at normal growth temperatures and is only minimally induced by hyperthermia. The rat hsp70-related sequence is part of a multigene family that extends across species to mice and humans.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/369178/9b3815f7d346/molcellb00142-0160-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/369178/67787f1a6b04/molcellb00142-0155-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/369178/0321a668e174/molcellb00142-0159-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/369178/308251a95314/molcellb00142-0159-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/369178/9b3815f7d346/molcellb00142-0160-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/369178/67787f1a6b04/molcellb00142-0155-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/369178/0321a668e174/molcellb00142-0159-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/369178/308251a95314/molcellb00142-0159-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/369178/9b3815f7d346/molcellb00142-0160-a.jpg

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本文引用的文献

1
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2
Cellular responses to stress: comparison of a family of 71--73-kilodalton proteins rapidly synthesized in rat tissue slices and canavanine-treated cells in culture.细胞对应激的反应：对大鼠组织切片和培养中经刀豆氨酸处理的细胞中快速合成的一组71 - 73千道尔顿蛋白质的比较。
J Cell Physiol. 1981 Aug;108(2):261-75. doi: 10.1002/jcp.1041080216.
3
Antibodies to two major chicken heat shock proteins cross-react with similar proteins in widely divergent species.
热休克应激后阻断 HSPA8 的核输出会严重改变细胞存活。
Sci Rep. 2018 Nov 14;8(1):16820. doi: 10.1038/s41598-018-34887-6.
4
Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction.热休克促进突变型亨廷顿蛋白（mHtt）形成包含体，并减轻 mHtt 诱导的转录因子功能障碍。
J Biol Chem. 2018 Oct 5;293(40):15581-15593. doi: 10.1074/jbc.RA118.002933. Epub 2018 Aug 24.
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Cell Stress Chaperones. 2014 Nov;19(6):949-61. doi: 10.1007/s12192-014-0519-2. Epub 2014 May 24.
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