Lundberg J J, Møllgård K
Neurosci Lett. 1979 Aug;13(3):265-70. doi: 10.1016/0304-3940(79)91505-2.
By implantation of pieces of fetal CNS into adult host brains it was found that the fetal brain tissue induced a very high mitotic activity in the adult brain at 2-4 days after implantation. The dividing cells were found within a 3-mm zone from the transplant in occipital cortex, hippocampus and brain-stem. Sham operated control animals exhibited only very few mitotic figures close to the lesion. Neither local injection of amniotic fluid nor implantation of other fetal tissues induced mitotic activity with the exception of fetal liver. Possibly, the mitogenic factor(s) released from the transplanted fetal brain is hepatic in origin.
通过将胎儿中枢神经系统组织块植入成年宿主脑内，发现胎儿脑组织在植入后2 - 4天可在成年脑内诱导出非常高的有丝分裂活性。在枕叶皮质、海马体和脑干中，在距移植组织3毫米的区域内发现了分裂细胞。假手术对照组动物仅在损伤部位附近出现极少的有丝分裂图像。除胎儿肝脏外，局部注射羊水或植入其他胎儿组织均未诱导有丝分裂活性。可能从移植的胎儿脑中释放的促有丝分裂因子起源于肝脏。
