Institute of Natural Products and Cosmetics, Faculty of Biotechnology and Food Sciences, Łódź University of Technology, Stefanowskiego Street 2/22, 90-537 Lodz, Poland.
Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna Street 12, 31-343 Krakow, Poland.
Molecules. 2024 Sep 30;29(19):4658. doi: 10.3390/molecules29194658.
, a species native to China, Korea, Japan, and Russia, has been used medicinally in the countries of its origin. Though mono- and sesquiterpenoids are known constituents of , the complete analysis of essential oils produced by the roots and aerial parts of the plant has not been published until now. The present study discloses considerable differences in the composition and cytotoxic activity of essential oils distilled from roots and shoots of . The GC-MS-FID analyses have led to the identification of 131 compounds in all, of which 114 were found in aerial parts and 110 in the roots of the plants. The essential oil distilled from shoots contained a mixture of nerol and thymol methyl ether (c. 26%), neryl isobutyrate (c. 12%) and linalool (c. 9%) as major constituents, whereas alantolactone (c. 29%), thymol methyl ether (c. 7%) and 2,5-dimethoxy--cymene (thymohydroquinone dimethyl ether, c. 7%) predominated in the essential oil obtained from the roots. The oils demonstrated weak antibacterial activity against and, at concentrations up to 2.08 mg/mL (oil from the aerial parts) and up to 3.38 mg/mL (oil from roots), were inactive against Gram-negative bacteria. The essential oil from the roots of the plant demonstrated strong but not selective cytotoxic activity.
, 一种原产于中国、韩国、日本和俄罗斯的物种，在其起源国被用于药用。虽然单萜和倍半萜类化合物是 的已知成分，但直到现在，尚未有关于植物根和地上部分产生的精油的完整分析。本研究揭示了从根和地上部分蒸馏的精油在组成和细胞毒性活性方面存在相当大的差异。GC-MS-FID 分析共鉴定出 131 种化合物，其中 114 种存在于地上部分，110 种存在于植物根部。从地上部分蒸馏得到的精油含有橙花醇和百里香甲醚（约 26%）、橙花酯（约 12%）和芳樟醇（约 9%）等主要成分，而从根部蒸馏得到的精油则以土木香内酯（约 29%）、百里香甲醚（约 7%）和 2,5-二甲氧基-对伞花烃（百里香氢醌二甲醚，约 7%）为主。这些精油对 和 表现出较弱的抗菌活性，在浓度高达 2.08 毫克/毫升（来自地上部分的油）和高达 3.38 毫克/毫升（来自根部的油）时，对革兰氏阴性菌无效。植物根部精油表现出强烈但非选择性的细胞毒性活性。
