Division of Bioanalysis, Biocomplete Inc., #603, 604, Hanshin IT Tower, 272 Digital-ro, Guro-gu, Seoul 08389, Republic of Korea.
Golden Biotechnology Corporation, Tamsui District, New Taipei City 251, Taiwan.
Nutrients. 2024 Oct 8;16(19):3406. doi: 10.3390/nu16193406.
BACKGROUND/OBJECTIVES: , also known as "Niuchangchih" in Taiwan, is a unique medicinal mushroom native to Taiwan. It is used in traditional medicine to treat various health conditions. In this study, we investigated the efficacy of mycelia on alcohol-induced liver damage, both in vitro and in vivo, in a Good Laboratory Practice (GLP) facility.
The experimental groups consisted of a normal control group (G1), a negative control group (G2), an mycelium powder 50 mg/kg/day administration group (G3), a 100 mg/kg/day administration group (G4), a 200 mg/kg/day administration group (G5), and a positive control silymarin 200 mg/kg/day administration group (G6), with 10 Sprague Dawley rats assigned to each treatment group.
We found that treatment with mycelium powder significantly reduced alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, cholesterol, adiponectin, triglyceride, and malondialdehyde concentrations. Histopathological analysis also revealed that the inflammation score significantly decreased in the -treated groups.
Based on these results, we conclude that repeated oral administration of mycelium powder is effective in improving alcoholic liver disease.
背景/目的：牛樟芝，又名“台湾樟芝”，是一种原产于台湾的独特药用蘑菇。在传统医学中，它被用于治疗各种健康状况。在这项在符合良好实验室规范（GLP）设施中进行的研究中，我们调查了樟芝菌丝体对酒精性肝损伤的体内和体外疗效。
实验组包括正常对照组（G1）、阴性对照组（G2）、樟芝菌丝体粉末 50mg/kg/天给药组（G3）、100mg/kg/天给药组（G4）、200mg/kg/天给药组（G5）和阳性对照物水飞蓟素 200mg/kg/天给药组（G6），每组有 10 只 Sprague Dawley 大鼠。
我们发现，樟芝菌丝体粉末治疗可显著降低丙氨酸氨基转移酶、天冬氨酸氨基转移酶、碱性磷酸酶、胆固醇、脂联素、甘油三酯和丙二醛浓度。组织病理学分析还表明，-治疗组的炎症评分显著降低。
基于这些结果，我们得出结论，重复口服樟芝菌丝体粉末可有效改善酒精性肝病。
