State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
Nat Prod Rep. 2021 Jan 1;38(1):83-102. doi: 10.1039/d0np00023j. Epub 2020 Jul 28.
Covering: up to February 2020Antrodia camphorata is a medicinal mushroom endemic to Taiwan for the treatment of intoxication, liver injury, cancer, and inflammation. Owing to its rare occurrence and potent pharmacological activities, efforts have been devoted to identify its bioactive constituents, especially terpenoids. Since 1995, a total of 162 terpenoids including triterpenoids, meroterpenoids, sesquiterpenoids, diterpenoids, and steroids have been characterized. The ergostane-type triterpenoids (antcins) and meroterpenoids (antroquinonols) are characteristic constituents of A. camphorata. The terpenoids show anti-cancer, hepatoprotective, anti-inflammatory, anti-diabetic, and neuroprotective activities. This review summarizes the research progress on terpenoids in A. camphorata during 1995-2020, including structural diversity, resources, biosynthesis, pharmacological activities, metabolism, and toxicity. The medicinal potential of the terpenoids is also discussed.
紫萁小菇是一种台湾特有的药用蘑菇，用于治疗中毒、肝损伤、癌症和炎症。由于其罕见的发生和强大的药理活性，人们一直致力于鉴定其生物活性成分，特别是萜类化合物。自 1995 年以来，共鉴定出 162 种萜类化合物，包括三萜类、倍半萜类、二萜类、甾体类等。麦角甾烷型三萜类（安斯菌素）和倍半萜类（安托醌醇）是紫萁小菇的特征成分。萜类化合物具有抗癌、保肝、抗炎、抗糖尿病和神经保护活性。本文综述了 1995-2020 年紫萁小菇萜类化合物的研究进展，包括结构多样性、资源、生物合成、药理活性、代谢和毒性。还讨论了萜类化合物的药用潜力。
