Sharma Shanu, Karande Geeta, Patil Satish
Department of Microbiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Satara, IND.
Cureus. 2024 Sep 16;16(9):e69538. doi: 10.7759/cureus.69538. eCollection 2024 Sep.
Enterobacteriaceae are a group of aerobic and facultative anaerobic Gram-negative bacilli known to cause various infections in healthy folks and those with preexisting health conditions.
Current research focuses on analyzing the bacteriological profile of clinical isolates, examining their antimicrobial susceptibility and the spectrum of drug resistance.
The study was conducted on patients admitted to the inpatient/outpatient department at Krishna Hospital, Karad. Clinical samples from patients with suspected infections, including pus, sputum, urine, blood, and other body fluids, were examined. The 156 bacterial isolates were identified using Gram staining and biochemical tests following the standard protocol.
Of the 156 isolates, was the most common isolate, with 79 (50.6%), followed by , with 52 (33.3%). The maximum resistance was demonstrated toward co-trimoxazole (96.3%), ciprofloxacin (88.7%), and ceftazidime (84.6%).
During the study, the prevalence of metallo-β-lactamase (MBL), extended-spectrum β-lactamase (ESBL), and AmpC increased significantly. The study data showed the overall prevalence of MBL, ESBL, and AmpC to be 67.3%, 37.8%, and 38.4%, respectively. Further, the rate of multidrug-resistant isolates was noteworthy (92.6%). Thus, comprehending the resistance pattern and epidemiology of the organism within a specific demographic area can help create better guidelines to curtail such infections.
肠杆菌科是一组需氧和兼性厌氧的革兰氏阴性杆菌，已知可在健康人群和已有健康问题的人群中引起各种感染。
当前的研究重点是分析临床分离株的细菌学特征，检测它们的抗菌敏感性和耐药谱。
该研究在卡拉德克里希纳医院住院部/门诊部收治的患者中进行。对疑似感染患者的临床样本进行检查，包括脓液、痰液、尿液、血液和其他体液。按照标准方案，通过革兰氏染色和生化试验对156株细菌分离株进行鉴定。
在156株分离株中， 是最常见的分离株，有79株（50.6%），其次是 ，有52株（33.3%）。对复方新诺明（96.3%）、环丙沙星（88.7%）和头孢他啶（84.6%）的耐药性最高。
在研究期间，金属β-内酰胺酶（MBL）、超广谱β-内酰胺酶（ESBL）和AmpC的流行率显著增加。研究数据显示，MBL、ESBL和AmpC的总体流行率分别为67.3%、37.8%和38.4%。此外，多重耐药分离株的比例值得注意（92.6%）。因此，了解特定人口区域内该生物体的耐药模式和流行病学情况有助于制定更好的指南以减少此类感染。
