University Hospital Essen, Department of Hematology and Stem Cell Transplantation, West German Cancer Center, German Cancer Consortium Partner Site Essen, Center for Molecular Biotechnology, University of Duisburg-Essen, Essen, Germany.
Methods Mol Biol. 2025;2865:411-428. doi: 10.1007/978-1-0716-4188-0_18.
Mouse models are an indispensable tool in lymphoma research. Here, we focus on the utilization of genetically engineered mouse models as preclinical avatars in lymphoma research. We describe lymphoma-relevant alleles and allele combinations, as well as general considerations for model selection. We further illustrate concepts of gene targeting and model design and provide guidelines for breeding strategies and colony maintenance.
小鼠模型是淋巴瘤研究中不可或缺的工具。在这里，我们重点介绍了遗传工程小鼠模型作为淋巴瘤研究中临床前模型的应用。我们描述了与淋巴瘤相关的等位基因和等位基因组合，以及模型选择的一般注意事项。我们进一步阐述了基因靶向和模型设计的概念，并提供了育种策略和品系维持的指导原则。
