空气污染与骨密度之间的关联：一项孟德尔随机化研究。
Association between air pollution and bone mineral density: a Mendelian randomization study.
作者信息
Jiang Rui, Qu Qi, Wang Zhiyu, Luo Feng, Mou Shuanglin
机构信息
Graduate School, Hubei University of Traditional Chinese Medicine, Wuhan, China.
Department of Orthopedics, Huanggang Hospital of Traditional Chinese Medicine, Huanggang, China.
出版信息
Arch Med Sci. 2024 Aug 28;20(4):1334-1338. doi: 10.5114/aoms/192628. eCollection 2024.
INTRODUCTION
The association of air pollution with bone mineral density (BMD) has attracted increasing attention. However, establishing a causal relationship remains uncertain.
METHODS
We conducted a Mendelian randomization (MR) study employing PM, PM, PM, nitrogen dioxide, and nitrogen oxides as exposures and BMD as the outcome to explore the causality between air pollution and the occurrence of decreased BMD.
RESULTS
By employing the IVW method, we identified a negative causality between air pollution (PM, PM, and nitrogen oxides) and BMD.
CONCLUSIONS
Our findings demonstrate that PM, PM and nitrogen oxides exposure may contribute to decreased BMD.
引言
空气污染与骨密度（BMD）之间的关联已引起越来越多的关注。然而，确定因果关系仍不确定。
方法
我们进行了一项孟德尔随机化（MR）研究，将细颗粒物（PM）、可吸入颗粒物（PM）、粗颗粒物（PM）、二氧化氮和氮氧化物作为暴露因素，骨密度作为结果，以探讨空气污染与骨密度降低发生之间的因果关系。
结果
通过采用逆方差加权（IVW）方法，我们确定了空气污染（细颗粒物、可吸入颗粒物和氮氧化物）与骨密度之间存在负向因果关系。
结论
我们的研究结果表明，接触细颗粒物、可吸入颗粒物和氮氧化物可能导致骨密度降低。
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