University of Monastir, Faculty of Medicine of Monastir, 5000, Hospital Fattouma Bourguiba Monastir, Service of Psychiatry, 5000, Monastir, Tunisia.
University of Sousse, Faculty of Medicine of Sousse, 4000, Hospital Farhat Hached, Sousse, Service of dermatology Sousse, Tunisia.
Tunis Med. 2024 Oct 5;102(10):659-663. doi: 10.62438/tunismed.v102i10.5119.
Introduction Alopecia areata (AA) is a common, chronic inflammatory, non-scarring form of hair loss affecting 0.1-0.2% of the population. It is a psychosomatic disease involving a T-cell-mediated immune reaction against hair follicle antigens during the anagen phase. Psychiatric morbidity in dermatological patients can significantly affect their quality of life and disease progression. Identifying and addressing these comorbidities in AA patients is crucial. Aim This study aimed to estimate the prevalence of depression and its associated factors among patients diagnosed with alopecia areata (AA). Methods The present study is a cross-sectional, descriptive, and analytical study conducted at Farhat Hached Hospital in Sousse, Tunisia, during the period from August to December 2019. Participants were recruited from the Dermatology Outpatient Department. The questionnaire covered socio-demographic characteristics, personal and family history, AA history, clinical presentation, disease severity (SALT score), nail involvement, and depression assessment using the Hamilton Depression Scale (validated Arabic version). Results A total of 60 AA patients were enrolled, with a mean age of 37.6 ± 12.9 years. Females exhibited a predominant representation, with a male to female ratio (M/F) of 0.76. According to the Hamilton Depression Scale (HAM-D), 31 cases (51.7%) were depressed, with a mean depression scale score of 11.33 (±6.57 SD). The presence of depression was significantly associated with younger age (p=0.018), the presence of the eyelashes/eyebrows form (p=0.035), nail involvement (p= 0.03), and a poor response to treatment (p=0.004). Conclusion Our research highlights the importance of providing psychological support to alopecia areata patients.
斑秃（AA）是一种常见的慢性炎症性非瘢痕性脱发，影响人群的 0.1-0.2%。它是一种涉及生长期毛囊抗原的 T 细胞介导免疫反应的身心疾病。皮肤科患者的精神疾病发病率会显著影响他们的生活质量和疾病进展。确定和解决 AA 患者的这些合并症至关重要。目的：本研究旨在评估斑秃（AA）患者中抑郁的患病率及其相关因素。方法：本研究为 2019 年 8 月至 12 月在突尼斯苏塞的 Farhat Hached 医院进行的横断面、描述性和分析性研究。参与者从皮肤科门诊招募。问卷涵盖了社会人口学特征、个人和家族史、AA 史、临床表现、疾病严重程度（SALT 评分）、指甲受累和使用汉密尔顿抑郁量表（经过验证的阿拉伯语版本）评估抑郁。结果：共纳入 60 例 AA 患者，平均年龄为 37.6±12.9 岁。女性占主导地位，男女比例为 0.76。根据汉密尔顿抑郁量表（HAM-D），31 例（51.7%）患者抑郁，平均抑郁量表得分为 11.33（±6.57 SD）。抑郁的存在与年龄较小（p=0.018）、睫毛/眉毛形式（p=0.035）、指甲受累（p=0.03）和治疗反应不佳（p=0.004）显著相关。结论：我们的研究强调了为斑秃患者提供心理支持的重要性。
