Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Sci Rep. 2024 Oct 24;14(1):25166. doi: 10.1038/s41598-024-76892-y.
Type I spiral ganglion neurons are peripheral neurons essential for hearing perception. While they can be subdivided in mice based on characteristic gene expression patterns, detailed examinations of these subtypes in primates and humans are lacking. In this study, we investigated the developmental subtypes of spiral ganglion neurons in the common marmoset (Callithrix jacchus). We confirmed that Type I spiral ganglion can be divided based on the characteristic gene expression patterns of several marker genes. However, some combinations of these genes differ from those in rodents, suggesting common marmoset's suitability for advancing our understanding of human cochlear development. Additionally, identifying the essential time points for subtype specifications and subsequent maturation will aid in studying the primate-specific developmental biology of the inner ear. This could lead to new treatment strategies for hearing loss in humans and be valuable for studying age-related hearing loss, as well as designing regenerative therapies.
I 型螺旋神经节神经元是听觉感知所必需的周围神经元。虽然它们可以根据特征基因表达模式在小鼠中细分，但在灵长类动物和人类中对这些亚型的详细研究还很缺乏。在这项研究中，我们调查了普通狨猴（Callithrix jacchus）螺旋神经节神经元的发育亚型。我们证实，I 型螺旋神经节可以根据几个标记基因的特征基因表达模式进行划分。然而，这些基因的某些组合与啮齿动物不同，这表明普通狨猴适合于深入了解人类耳蜗的发育。此外，确定亚型特化和随后成熟的关键时间点将有助于研究内耳的灵长类动物特异性发育生物学。这可能为人类听力损失的治疗策略提供新的思路，并有助于研究与年龄相关的听力损失，以及设计再生治疗方法。
