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利用机器学习识别急诊科误诊患者亚组:多中心概念验证研究。

Leveraging Machine Learning to Identify Subgroups of Misclassified Patients in the Emergency Department: Multicenter Proof-of-Concept Study.

作者信息

Wyatt Sage, Lunde Markussen Dagfinn, Haizoune Mounir, Vestbø Anders Strand, Sima Yeneabeba Tilahun, Sandboe Maria Ilene, Landschulze Marcus, Bartsch Hauke, Sauer Christopher Martin

机构信息

Department of Global Public Health, Faculty of Medicine, University of Bergen, Bergen, Norway.

Department of Emergency Medicine, Haukeland University Hospital, Bergen, Norway.

出版信息

J Med Internet Res. 2024 Dec 31;26:e56382. doi: 10.2196/56382.

Abstract

BACKGROUND

Hospitals use triage systems to prioritize the needs of patients within available resources. Misclassification of a patient can lead to either adverse outcomes in a patient who did not receive appropriate care in the case of undertriage or a waste of hospital resources in the case of overtriage. Recent advances in machine learning algorithms allow for the quantification of variables important to under- and overtriage.

OBJECTIVE

This study aimed to identify clinical features most strongly associated with triage misclassification using a machine learning classification model to capture nonlinear relationships.

METHODS

Multicenter retrospective cohort data from 2 big regional hospitals in Norway were extracted. The South African Triage System is used at Bergen University Hospital, and the Rapid Emergency Triage and Treatment System is used at Trondheim University Hospital. Variables included triage score, age, sex, arrival time, subject area affiliation, reason for emergency department contact, discharge location, level of care, and time of death were retrieved. Random forest classification models were used to identify features with the strongest association with overtriage and undertriage in clinical practice in Bergen and Trondheim. We reported variable importance as SHAP (SHapley Additive exPlanations)-values.

RESULTS

We collected data on 205,488 patient records from Bergen University Hospital and 304,997 patient records from Trondheim University Hospital. Overall, overtriage was very uncommon at both hospitals (all <0.1%), with undertriage differing between both locations, with 0.8% at Bergen and 0.2% at Trondheim University Hospital. Demographics were similar for both hospitals. However, the percentage given a high-priority triage score (red or orange) was higher in Bergen (24%) compared with 9% in Trondheim. The clinical referral department was found to be the variable with the strongest association with undertriage (mean SHAP +0.62 and +0.37 for Bergen and Trondheim, respectively).

CONCLUSIONS

We identified subgroups of patients consistently undertriaged using 2 common triage systems. While the importance of clinical patient characteristics to triage misclassification varies by triage system and location, we found consistent evidence between the two locations that the clinical referral department is the most important variable associated with triage misclassification. Replication of this approach at other centers could help to further improve triage scoring systems and improve patient care worldwide.

摘要

背景

医院使用分诊系统在可用资源范围内对患者的需求进行优先排序。患者分类错误可能导致在分诊不足的情况下未得到适当护理的患者出现不良后果,或者在分诊过度的情况下造成医院资源的浪费。机器学习算法的最新进展使得对分诊不足和分诊过度重要的变量进行量化成为可能。

目的

本研究旨在使用机器学习分类模型识别与分诊错误分类最密切相关的临床特征,以捕捉非线性关系。

方法

提取了挪威两家大型地区医院的多中心回顾性队列数据。卑尔根大学医院使用南非分诊系统,特隆赫姆大学医院使用快速急诊分诊与治疗系统。检索的变量包括分诊分数、年龄、性别、到达时间、学科领域归属、急诊科就诊原因、出院地点、护理级别和死亡时间。随机森林分类模型用于识别卑尔根和特隆赫姆临床实践中与分诊过度和分诊不足关联最强的特征。我们将变量重要性报告为SHAP(SHapley加法解释)值。

结果

我们收集了卑尔根大学医院205488份患者记录和特隆赫姆大学医院304997份患者记录的数据。总体而言,两家医院的分诊过度情况都非常少见(均<0.1%),分诊不足情况在两个地点有所不同,卑尔根为0.8%,特隆赫姆大学医院为0.2%。两家医院的人口统计学特征相似。然而,卑尔根给予高优先级分诊分数(红色或橙色)的百分比(24%)高于特隆赫姆的9%。临床转诊科室被发现是与分诊不足关联最强的变量(卑尔根和特隆赫姆的平均SHAP值分别为+0.62和+0.37)。

结论

我们使用两种常见的分诊系统确定了持续被分诊不足的患者亚组。虽然临床患者特征对分诊错误分类的重要性因分诊系统和地点而异,但我们在两个地点发现了一致的证据,即临床转诊科室是与分诊错误分类相关的最重要变量。在其他中心重复这种方法有助于进一步改进分诊评分系统并改善全球患者护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3133/11733519/6f648c5bca17/jmir_v26i1e56382_fig1.jpg

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