Karageorgos Filippos F, Alexiou Maria, Tsoulfas Georgios, Alexopoulos Aleck H
Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University of Thessaloniki School of Medicine, 54642 Thessaloniki, Greece.
Chemical Process & Energy Resources Institute, 6th Km Harilaou-Thermi Rd., P.O. Box 60361, 57001 Thessaloniki, Greece.
Gels. 2024 Oct 12;10(10):653. doi: 10.3390/gels10100653.
Biomedical engineering, especially tissue engineering, is trying to provide an alternative solution to generate functional organs/tissues for use in various applications. These include beyond the final goal of transplantation, disease modeling and drug discovery as well. The aim of this study is to comprehensively review the existing literature on hydrogel-based vascularized organ (i.e., liver, pancreas, kidneys, intestine, stomach and spleen) tissue engineering of the abdominal organs.
A comprehensive literature search was conducted on the Scopus database (latest search 1 September 2024). The research studies including hydrogel-based vascularized organ tissue engineering in the organs examined here were eligible for the review.
Herein, 18 studies were included. Specifically, 10 studies included the liver or hepatic tissue, 5 studies included the pancreas or pancreatic islet tissue, 3 studies included the kidney or renal tissue, 1 study included the intestine or intestinal or bowel tissue, 1 study included the stomach or gastric tissue, and 0 studies included spleen tissue.
Hydrogels are biocompatible materials with ideal characteristics for use as scaffolds. Even though organ tissue engineering is a rapidly growing field, there are still many obstacles to overcome to create a fully functional and long-lasting organ.
生物医学工程，尤其是组织工程，正试图提供一种替代解决方案，以生成用于各种应用的功能性器官/组织。这些应用不仅包括移植的最终目标，还包括疾病建模和药物发现。本研究的目的是全面综述关于基于水凝胶的腹部器官（即肝脏、胰腺、肾脏、肠道、胃和脾脏）血管化器官组织工程的现有文献。
在Scopus数据库上进行了全面的文献检索（最新检索时间为2024年9月1日）。在此处研究的器官中，包括基于水凝胶的血管化器官组织工程的研究符合纳入综述的条件。
本文纳入了18项研究。具体而言，10项研究涉及肝脏或肝组织，5项研究涉及胰腺或胰岛组织，3项研究涉及肾脏或肾组织，1项研究涉及肠道或肠组织，1项研究涉及胃或胃组织，0项研究涉及脾脏组织。
水凝胶是具有理想特性的生物相容性材料，可用作支架。尽管器官组织工程是一个快速发展的领域，但要创建一个功能完全且持久的器官，仍有许多障碍需要克服。
