Sheptulina Anna F, Lyusina Ekaterina O, Mamutova Elvira M, Yafarova Adel A, Kiselev Anton R, Drapkina Oxana M
Department of Fundamental and Applied Aspects of Obesity, National Medical Research Center for Therapy and Preventive Medicine, 101990 Moscow, Russia.
Department of Therapy and Preventive Medicine, A.I. Evdokimov Moscow State University of Medicine and Dentistry, 127473 Moscow, Russia.
Diagnostics (Basel). 2024 Oct 16;14(20):2301. doi: 10.3390/diagnostics14202301.
Body composition (BC) affects the risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD) and hypertension (HTN). Currently, dual-energy X-ray absorptiometry (DEXA) is considered the gold standard for assessing BC, even though it has some limitations, including immobility, ionizing radiation, and patient weight restrictions. The aim of the study was to evaluate the correlations of BC parameters measured by bioelectrical impedance analysis (BIA) with those measured by DEXA in patients with MASLD and HTN. Overall, 78 patients with MASLD and HTN underwent the following study procedures: compilation of an anamnesis, physical examination of a patient, laboratory tests, abdominal ultrasound, BIA, DEXA, and anthropometric measurements. The agreement between BIA and DEXA in diagnosing reduced skeletal muscle mass (SMM) in patients with MASLD and HTN was moderate (kappa values were 0.440 and 0.404 in males and females, respectively). Significant strong direct correlations were found between fat mass (FM) and body fat percentage measured by BIA with corresponding measurements by DEXA ( < 0.001 for both). The area under the receiver operating characteristic curves (AUC) of SMM to body weight ratios calculated using BIA data were 0.834 and 0.929 for reduced appendicular SMM determined by DEXA in males and females with MASLD and HTN, respectively. In conclusion, BIA is an easy-to-use and widely available tool for assessing SMM and FM in patients with MASLD and HTN, demonstrating reliable agreement with DEXA measurement results and completely free of its limitations.
身体成分（BC）会影响发生代谢功能障碍相关脂肪性肝病（MASLD）和高血压（HTN）的风险。目前，双能X线吸收法（DEXA）被认为是评估身体成分的金标准，尽管它存在一些局限性，包括需要保持静止、存在电离辐射以及对患者体重有限制。本研究的目的是评估在患有MASLD和HTN的患者中，通过生物电阻抗分析（BIA）测量的身体成分参数与通过DEXA测量的参数之间的相关性。总体而言，78例患有MASLD和HTN的患者接受了以下研究程序：收集病史、对患者进行体格检查、实验室检查、腹部超声、BIA、DEXA以及人体测量。在患有MASLD和HTN的患者中，BIA和DEXA在诊断骨骼肌质量（SMM）降低方面的一致性为中等（男性和女性的kappa值分别为0.440和0.404）。发现通过BIA测量的脂肪量（FM）和体脂百分比与通过DEXA进行的相应测量之间存在显著的强直接相关性（两者均P<0.001）。使用BIA数据计算的SMM与体重比的受试者工作特征曲线下面积（AUC），对于通过DEXA确定的患有MASLD和HTN的男性和女性的四肢SMM降低，分别为0.834和0.929。总之，BIA是一种易于使用且广泛可用的工具，用于评估患有MASLD和HTN的患者的SMM和FM，与DEXA测量结果显示出可靠的一致性，并且完全没有其局限性。
